Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 12/20 | 0.64 |
| ▸ | RARG | P13631 | 12/20 | 0.64 |
| ▸ | RARA | P10276 | 11/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9145742 | 1.00 | RARB (0.64) | RARBRARGRARAALDH1A1RAB9A | |
| SCHEMBL8522590 | 0.85 | RARG (0.62) | RARBRARGRARAALDH1A1RAB9A | |
| SCHEMBL8522592 | 0.85 | RARG (0.62) | RARBRARGRARAALDH1A1RAB9A | |
| SCHEMBL24401018 | 0.83 | ALOX5 (0.50) | RARBRARGALDH1A1RAB9ANPC1 | |
| SCHEMBL26722153 | 0.78 | RARB (1.00) | RARBRARGRARAALDH1A1RAB9A | |
| SCHEMBL10556851 | 0.76 | RARB (1.00) | RARBRARGRARAALDH1A1RAB9A | |
| SCHEMBL10556841 | 0.76 | RARB (1.00) | RARBRARGRARAALDH1A1RAB9A | |
| SCHEMBL12367125 | 0.75 | MAPT (0.41) | RARBRARGRARAALDH1A1RAB9A | |
| SCHEMBL9142620 | 0.74 | RARB (0.61) | RARBRARGRARAALDH1A1RAB9A | |
| SCHEMBL9142618 | 0.74 | RARB (0.61) | RARBRARGRARAALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0350846-B1 | Condensed heterocyclic compounds and their use in therapy | HOFFMANN LA ROCHE (CH) | 1995-10-11 | — | — | EP | claimed |
| US-5420273-A | Skin disorders and antitumor agents | HOFFMAN-LA ROCHE INC. (US) | 1995-05-30 | — | — | US | disclosed |
| US-5300522-A | Treating inflammatory, allergic, rheumatic, immunological disorders | HOFFMANN-LA ROCHE INC. (US) | 1994-04-05 | — | — | US | disclosed |
| US-5164387-A | Antitumor agents, skin disorders, antiinflammatory agents | HOFFMANN-LAROCHE INC. (US) | 1992-11-17 | — | — | US | disclosed |
| US-5037825-A | Useful In The Treatment Of Neoplasms, Dermatoses And Aging Of The Skin | HOFFMANN-LA ROCHE INC. (US) | 1991-08-06 | — | — | US | disclosed |