Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388267 | 0.82 | DHFR (1.00) | DHFRADORA1ADORA2AFGFR1SRC | |
| SCHEMBL1388741 | 0.80 | DHFR (0.79) | DHFRADORA1ADORA2AFGFR1SRC | |
| SCHEMBL1388760 | 0.75 | DHFR (0.74) | DHFRADORA1ADORA2AFGFR1SRC | |
| SCHEMBL1388517 | 0.75 | DHFR (0.74) | DHFRADORA1ADORA2AFGFR1SRC | |
| SCHEMBL1388506 | 0.73 | DHFR (0.67) | DHFRLMNA | |
| SCHEMBL29913206 | 0.73 | DHFR (0.67) | DHFRLMNA | |
| SCHEMBL1388763 | 0.72 | DHFR (1.00) | DHFRADORA1ALDH1A1 | |
| SCHEMBL7273497 | 0.72 | DHFR (0.70) | DHFRADORA1ADORA2AFGFR1SRC | |
| SCHEMBL1388629 | 0.71 | ADORA1 (0.70) | DHFRADORA1ADORA2A | |
| SCHEMBL1388616 | 0.71 | DHFR (0.63) | DHFRADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674627-A1 | PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014780-A1 | PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-07-07 | — | — | WO | disclosed |