Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9148301 | 0.93 | CHRM2 (0.36) | CHRM2CHRM1CHRNA7 | |
| SCHEMBL9148310 | 0.92 | CHRNA7 (0.45) | CHRM2CHRM1CHRNA7 | |
| Oxalic Acid SCHEMBL9151395 | 0.85 | CHRNA7 (0.40) | CHRNA7 | |
| SCHEMBL9148633 | 0.81 | CHRM2 (0.53) | CHRM2CHRM1 | |
| SCHEMBL9155101 | 0.79 | CHRM2 (0.41) | CHRM2CHRM1 | |
| SCHEMBL9147996 | 0.79 | CHRM2 (0.51) | CHRM2CHRM1 | |
| SCHEMBL9152399 | 0.76 | CHRM2 (0.41) | CHRM2CHRM1 | |
| SCHEMBL9155300 | 0.76 | CHRM2 (0.41) | CHRM2CHRM1 | |
| SCHEMBL9147958 | 0.76 | CHRM2 (0.41) | CHRM2CHRM1 | |
| SCHEMBL9150033 | 0.76 | CHRM2 (0.44) | CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405853-A | Potent muscarinic agonists having good central nervous system penetrability | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-11 | — | — | US | claimed |
| EP-0307142-B1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-09-14 | — | — | EP | claimed |
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | claimed |
| US-5405853-A | Potent muscarinic agonists having good central nervous system penetrability | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-11 | — | — | US | disclosed |
| EP-0307142-B1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-09-14 | — | — | EP | disclosed |
| US-5134146-A | SUBSTITUTED OXADIAZOLES AND THIADIAZOLES FOR USE IN THE TREATMENT OF GLAUCOMA | MERCK SHARP AND DOHME LTD. (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | disclosed |