Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9153257 | 0.95 | EPHX2 (0.46) | EPHX2L3MBTL1ALDH1A1TDP1HTT | |
| SCHEMBL9152709 | 0.89 | ALDH1A1 (0.49) | EPHX2ALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL17402500 | 0.87 | EPHX2 (0.52) | EPHX2L3MBTL1ALDH1A1TDP1FAAH | |
| SCHEMBL14949713 | 0.86 | ALDH1A1 (0.46) | EPHX2ALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL3525287 | 0.86 | EPHX2 (0.54) | EPHX2L3MBTL1ALDH1A1TDP1FAAH | |
| SCHEMBL18641735 | 0.86 | EPHX2 (0.54) | EPHX2L3MBTL1ALDH1A1TDP1FAAH | |
| SCHEMBL27274906 | 0.86 | EPHX2 (0.54) | EPHX2L3MBTL1ALDH1A1TDP1FAAH | |
| SCHEMBL25269510 | 0.85 | EPHX2 (0.57) | EPHX2L3MBTL1TDP1FAAHHTT | |
| SCHEMBL19032713 | 0.85 | EPHX2 (0.57) | EPHX2L3MBTL1TDP1FAAHHTT | |
| SCHEMBL10081325 | 0.85 | EPHX2 (0.57) | EPHX2L3MBTL1TDP1FAAHHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389659-A | Hypotensive agents | GLAXO GROUP LIMITED (GB) | 1995-02-14 | — | — | US | disclosed |
| WO-1993005025-A1 | C-LINKED PYRAZOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-03-18 | — | — | WO | disclosed |
| EP-0446062-A1 | C-Linked pyrazole derivatives | GLAXO GROUP LIMITED (GB) | 1991-09-11 | — | — | EP | disclosed |