Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369933 | 0.90 | MLNR (0.57) | MLNRCACNA1FNR1I2ABCB11ABCB1 | |
| SCHEMBL9147804 | 0.89 | MLNR (0.51) | MLNRCACNA1FNR1I2ABCB11ABCB1 | |
| SCHEMBL9149569 | 0.88 | DRD2 (0.55) | MLNRCACNA1FNR1I2ABCB11ABCB1 | |
| SCHEMBL9150043 | 0.85 | MLNR (0.53) | MLNRCACNA1FNR1I2ABCB11ABCB1 | |
| SCHEMBL9149853 | 0.84 | MLNR (0.55) | MLNRCACNA1FNR1I2ABCB11ABCB1 | |
| SCHEMBL9146213 | 0.84 | MLNR (0.51) | MLNRCACNA1FNR1I2ABCB11ABCB1 | |
| SCHEMBL9153253 | 0.83 | KCNH2 (0.59) | MLNRCACNA1FNR1I2ABCB11ABCB1 | |
| SCHEMBL9149558 | 0.83 | DRD2 (0.54) | MLNRCACNA1FNR1I2ABCB11ABCB1 | |
| SCHEMBL9153377 | 0.82 | MLNR (0.50) | MLNRCACNA1FNR1I2ABCB11ABCB1 | |
| SCHEMBL9150189 | 0.82 | MLNR (0.54) | MLNRCACNA1FNR1I2ABCB11ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5457115-A | Treating anxiety, depression, sleep disorders, migranes, schizophrenia or Parkinson's disease in humans | H. LUNDBECK A/S (DK) | 1995-10-10 | — | — | US | claimed |
| US-5457115-A | Treating anxiety, depression, sleep disorders, migranes, schizophrenia or Parkinson's disease in humans | H. LUNDBECK A/S (DK) | 1995-10-10 | — | — | US | disclosed |
| EP-0465398-B1 | Novel indole derivatives | LUNDBECK & CO AS H (DK) | 1994-12-14 | — | — | EP | disclosed |
| US-5322851-A | Indole derivatives | H. LUNDBECK A/S (DK) | 1994-06-21 | — | — | US | disclosed |
| US-5216001-A | Central nervous system disorders | H. LUNBECK A/S (DK) | 1993-06-01 | — | — | US | disclosed |
| EP-0465398-A2 | Novel indole derivatives | H. LUNDBECK A/S (DK) | 1992-01-08 | — | — | EP | disclosed |