Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.51 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9577523 | 0.86 | ALOX5 (0.58) | ALOX5MAPK1KMT2ASMN1; SMN2CYSLTR2 | |
| SCHEMBL10656521 | 0.85 | ALOX5 (0.69) | ALOX5MAPK1KMT2ASMN1; SMN2CYSLTR2 | |
| SCHEMBL9577510 | 0.83 | ALOX5 (0.60) | ALOX5MAPK1KMT2ASMN1; SMN2CYSLTR2 | |
| SCHEMBL9151507 | 0.81 | MRGPRX4 (0.51) | ALOX5KMT2ASMN1; SMN2MRGPRX4FFAR1 | |
| SCHEMBL9151796 | 0.79 | ALOX5 (0.43) | ALOX5KMT2ASMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL9147208 | 0.79 | ALOX5 (0.49) | ALOX5KMT2ASMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL9148495 | 0.79 | ALOX5 (0.53) | ALOX5KMT2ASMN1; SMN2MRGPRX4 | |
| SCHEMBL8459676 | 0.79 | FDFT1 (0.52) | PTGS1FFAR1 | |
| SCHEMBL9577515 | 0.78 | CYP4F2 (0.59) | ALOX5MAPK1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL27958523 | 0.78 | SLC6A2 (0.43) | ALOX5MAPK1KMT2ASMN1; SMN2CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666849-A4 | ARYL AND HETEROARYLMETHOXYPHENYL INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS. | ABBOTT LAB (US) | 1995-12-13 | — | — | EP | disclosed |
| EP-0666849-A1 | ARYL AND HETEROARYLMETHOXYPHENYL INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1995-08-16 | — | — | EP | disclosed |
| US-5358955-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1994-10-25 | — | — | US | disclosed |
| WO-1994010148-A1 | ARYL AND HETEROARYLMETHOXYPHENYL INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1994-05-11 | — | — | WO | disclosed |