Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.44 |
| ▸ | ALB | P02768 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | POLG | P54098 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8662563 | 1.00 | LMNA (0.46) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL8887323 | 0.87 | LMNA (0.45) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL15046170 | 0.81 | LMNA (0.50) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL19052854 | 0.75 | PDE3A (0.43) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL19052788 | 0.75 | PDE3A (0.43) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL9152242 | 0.75 | LMNA (0.40) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL8885064 | 0.75 | ALB (0.32) | ALB | |
| SCHEMBL10098889 | 0.75 | ALB (0.47) | ALBPOLG | |
| SCHEMBL307573 | 0.75 | ALB (0.47) | ALBPOLG | |
| SCHEMBL30107634 | 0.74 | POLB (0.51) | LMNATHRBMTORMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369409-B1 | Carbocyclic nucleosides and nucleotides | ACAD OF SCIENCE CZECH REPUBLIC (CS) | 1995-01-04 | — | — | EP | disclosed |
| EP-0369409-A1 | Carbocyclic nucleosides and nucleotides | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) | 1990-05-23 | — | — | EP | disclosed |