SCHEMBL9150891

SCHEMBL9150891

CC1(C)Oc2ccc(C#N)cc2[C@@H](Nc2ccc(Cl)cc2)[C@@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ABCC9 O60706 13/20 0.70
ABCB1 P08183 6/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9150894 1.00 ABCC9 (0.70) ABCC9ABCB1
SCHEMBL9150902 1.00 ABCC9 (0.70) ABCC9ABCB1
SCHEMBL11027377 0.88 ABCB1 (0.70) ABCC9ABCB1
SCHEMBL10507350 0.88 ABCB1 (0.70) ABCC9ABCB1
SCHEMBL11027376 0.88 ABCB1 (0.70) ABCC9ABCB1
SCHEMBL10507344 0.88 ABCB1 (0.70) ABCC9ABCB1
SCHEMBL9416601 0.85 ABCC9 (0.68) ABCC9ABCB1
SCHEMBL9416604 0.85 ABCC9 (0.68) ABCC9ABCB1
SCHEMBL8613567 0.84 ABCC9 (0.59) ABCC9ABCB1
SCHEMBL8938937 0.82 ABCC9 (0.65) ABCC9ABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0370901-B1 Central nervous system active chromane derivatives, process for their preparation and pharmaceutical compositions containing them SANOFI SA (FR) 1995-02-01 EP claimed
US-5082858-A Antidepressants SANOFI (FR) 1992-01-21 US claimed
JP-3014574-A None JP disclosed
US-5151442-A Cardiovascular disorders and nervous system disorders SANOFI (FR) 1992-09-29 US disclosed
US-5082858-A Antidepressants SANOFI (FR) 1992-01-21 US disclosed
JP-H0314574-A NEW CHROMAN DERIVATIVE ACTIVE ON CENTRAL NERVOUS SYSTEM, ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING IT SANOFI SA 1991-01-23 JP disclosed