Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 13/20 | 0.40 |
| ▸ | HTR2A | P28223 | 9/20 | 0.40 |
| ▸ | HTR2B | P41595 | 7/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9147224 | 0.77 | CHRM2 (0.47) | HTR2CHTR2AHTR2BCHRM4CHRM5 | |
| SCHEMBL9155273 | 0.74 | CHRM1 (0.46) | CHRM4CHRM1HTR6CHRM2 | |
| SCHEMBL10518762 | 0.74 | CHRM2 (0.60) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| Hydrochloric Acid SCHEMBL10518564 | 0.73 | CHRM2 (0.58) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL9155409 | 0.71 | HTR2A (0.40) | HTR2CHTR2AHTR2BCHRM4CHRM5 | |
| SCHEMBL9149638 | 0.71 | HTR2A (0.38) | HTR2CHTR2AHTR2BCHRM4CHRM5 | |
| SCHEMBL9148850 | 0.71 | HTR2A (0.41) | HTR2CHTR2AHTR2BCHRM4CHRM5 | |
| SCHEMBL9151139 | 0.71 | HTR2A (0.35) | HTR2CHTR2AHTR2BCHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL9148160 | 0.70 | HTR2A (0.37) | HTR2CHTR2AHTR2BCHRM4CHRM5 | |
| SCHEMBL9152691 | 0.69 | HTR2A (0.36) | HTR2CHTR2AHTR2BCHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405853-A | Potent muscarinic agonists having good central nervous system penetrability | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-11 | — | — | US | claimed |
| EP-0307142-B1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-09-14 | — | — | EP | claimed |
| EP-0307142-A1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | claimed |
| US-5405853-A | Potent muscarinic agonists having good central nervous system penetrability | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-11 | — | — | US | disclosed |
| EP-0307142-B1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-09-14 | — | — | EP | disclosed |
| EP-0307142-A1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |