Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9151130 | 0.81 | CHRM1 (0.49) | CHRM1CHRM2CHRM4 | |
| SCHEMBL9154745 | 0.79 | CHRM1 (0.56) | CHRM1CHRM2CHRM4 | |
| SCHEMBL9151387 | 0.74 | HTR2C (0.40) | CHRM1CHRM2HTR6CHRM4 | |
| SCHEMBL9151015 | 0.74 | CHRM1 (0.48) | CHRM1CHRM2CHRM4 | |
| SCHEMBL9151534 | 0.73 | CHRM1 (0.44) | CHRM1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL9154554 | 0.73 | CHRM1 (0.47) | CHRM1CHRM2CHRM4 | |
| SCHEMBL9149768 | 0.73 | CHRM1 (0.47) | CHRM1CHRM2CHRM4 | |
| SCHEMBL9148039 | 0.72 | CHRM1 (0.54) | CHRM1CHRM2CHRM4 | |
| SCHEMBL9152503 | 0.70 | CHRM1 (0.44) | CHRM1CHRM2CHRM4 | |
| SCHEMBL9152324 | 0.70 | CHRM1 (0.44) | CHRM1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405853-A | Potent muscarinic agonists having good central nervous system penetrability | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-11 | — | — | US | claimed |
| EP-0307142-B1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-09-14 | — | — | EP | claimed |
| EP-0307142-A1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | claimed |
| US-5405853-A | Potent muscarinic agonists having good central nervous system penetrability | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-11 | — | — | US | disclosed |
| EP-0307142-B1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-09-14 | — | — | EP | disclosed |
| EP-0307142-A1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |