Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2745264 | 0.75 | HRH3 (0.45) | MEN1KMT2ACCNA2CDK2CCNA1 | |
| SCHEMBL2745568 | 0.74 | HRH3 (0.47) | MEN1KMT2ACCNA2CDK2CCNA1 | |
| SCHEMBL2746051 | 0.72 | HRH2 (0.41) | HRH4 | |
| SCHEMBL27356363 | 0.72 | MEN1 (0.40) | MEN1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL27631803 | 0.71 | DHFR (0.40) | SMN1; SMN2 | |
| SCHEMBL10002364 | 0.69 | CDK2 (0.39) | MEN1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL9360365 | 0.68 | CDK2 (0.34) | MEN1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL8608363 | 0.67 | MEN1 (0.39) | MEN1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL28062920 | 0.66 | MEN1 (0.35) | MEN1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL11114694 | 0.65 | MEN1 (0.40) | MEN1CYP2D6CYP2C19KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557301-B1 | 5-FLUORO-2,4,6-PYRIMIDINETRIAMINE COMPOUNDS FOR PREVENTING HAIR LOSS | UPJOHN CO (US) | 1995-03-22 | — | — | EP | claimed |
| US-5373012-A | Useful in treatment of hair growth and cardiovascular disorder | THE UPJOHN COMPANY (US) | 1994-12-13 | — | — | US | claimed |
| EP-0557301-A1 | 5-FLUORO-2,4,6-PYRIMIDINETRIAMINE COMPOUNDS. | UPJOHN CO (US) | 1993-09-01 | — | — | EP | claimed |
| WO-1992008705-A1 | 5-FLUORO-2,4,6-PYRIMIDINETRIAMINE COMPOUNDS | THE UPJOHN COMPANY (US) | 1992-05-29 | — | — | WO | claimed |
| EP-0557301-B1 | 5-FLUORO-2,4,6-PYRIMIDINETRIAMINE COMPOUNDS FOR PREVENTING HAIR LOSS | UPJOHN CO (US) | 1995-03-22 | — | — | EP | disclosed |
| US-5373012-A | Useful in treatment of hair growth and cardiovascular disorder | THE UPJOHN COMPANY (US) | 1994-12-13 | — | — | US | disclosed |
| EP-0557301-A1 | 5-FLUORO-2,4,6-PYRIMIDINETRIAMINE COMPOUNDS. | UPJOHN CO (US) | 1993-09-01 | — | — | EP | disclosed |
| WO-1992008705-A1 | 5-FLUORO-2,4,6-PYRIMIDINETRIAMINE COMPOUNDS | THE UPJOHN COMPANY (US) | 1992-05-29 | — | — | WO | disclosed |