Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC13A5 | Q86YT5 | 9/20 | 0.32 |
| ▸ | SLC13A2 | Q13183 | 1/20 | 0.30 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL428392 | 0.88 | ALDH1A1 (0.46) | ALDH1A1MAPTKDM4ELMNAALOX15 | |
| Citric Acid SCHEMBL29173023 | 0.88 | ALDH1A1 (0.46) | ALDH1A1MAPTKDM4ELMNAALOX15 | |
| Citric Acid SCHEMBL1173327 | 0.88 | ALDH1A1 (0.46) | ALDH1A1MAPTKDM4ELMNAALOX15 | |
| Citric Acid SCHEMBL428255 | 0.88 | ALDH1A1 (0.46) | ALDH1A1MAPTKDM4ELMNAALOX15 | |
| SCHEMBL1173325 | 0.85 | ALDH1A1 (0.43) | ALDH1A1MAPTKDM4ELMNAALOX15 | |
| Citric Acid SCHEMBL424594 | 0.84 | ALDH1A1 (0.48) | ALDH1A1MAPTKDM4ELMNAALOX15 | |
| SCHEMBL9635618 | 0.84 | ALDH1A1 (0.39) | ALDH1A1MAPTKDM4ELMNAALOX15 | |
| SCHEMBL9614600 | 0.78 | TDP1 (0.34) | ALDH1A1 | |
| Acetic Acid SCHEMBL2519346 | 0.78 | — | — | |
| SCHEMBL5866476 | 0.78 | TDP1 (0.34) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481041-B1 | CITRATE ESTER COMPOSITIONS AND PROCESSES FOR THEIR PREPARATION | OWENS CORNING FIBERGLASS CORP (US) | 1995-01-11 | — | — | EP | claimed |
| EP-0493564-A1 | THERMOPLASTIC LOW-PROFILE ADDITIVES AND USE THEREOF IN UNSATURATED POLYESTER RESIN COMPOSITIONS | OWENS-CORNING FIBERGLAS CORPORATION (US) | 1992-07-08 | — | — | EP | claimed |
| EP-0481041-A1 | CITRATE ESTER COMPOSITIONS AND PROCESSES FOR THEIR PREPARATION. | OWENS CORNING FIBERGLASS CORP (US) | 1992-04-22 | — | — | EP | claimed |
| US-5102926-A | For use as placizers in molding materials of automobile panels | OWENS-CORNING FIBERGLAS CORPORATION (US) | 1992-04-07 | — | — | US | claimed |
| WO-1992001727-A1 | THERMOPLASTIC LOW-PROFILE ADDITIVES AND USE THEREOF IN UNSATURATED POLYESTER RESIN COMPOSITIONS | OWENS-CORNING FIBERGLAS CORPORATION (US) | 1992-02-06 | — | — | WO | claimed |
| WO-1991017136-A1 | CITRATE ESTER COMPOSITIONS AND PROCESSES FOR THEIR PREPARATION | OWENS-CORNING FIBERGLAS CORPORATION (US) | 1991-11-14 | — | — | WO | claimed |
| EP-0481041-B1 | CITRATE ESTER COMPOSITIONS AND PROCESSES FOR THEIR PREPARATION | OWENS CORNING FIBERGLASS CORP (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0493564-A1 | THERMOPLASTIC LOW-PROFILE ADDITIVES AND USE THEREOF IN UNSATURATED POLYESTER RESIN COMPOSITIONS | OWENS-CORNING FIBERGLAS CORPORATION (US) | 1992-07-08 | — | — | EP | disclosed |
| EP-0481041-A1 | CITRATE ESTER COMPOSITIONS AND PROCESSES FOR THEIR PREPARATION. | OWENS CORNING FIBERGLASS CORP (US) | 1992-04-22 | — | — | EP | disclosed |
| US-5102926-A | For use as placizers in molding materials of automobile panels | OWENS-CORNING FIBERGLAS CORPORATION (US) | 1992-04-07 | — | — | US | disclosed |
| WO-1992001727-A1 | THERMOPLASTIC LOW-PROFILE ADDITIVES AND USE THEREOF IN UNSATURATED POLYESTER RESIN COMPOSITIONS | OWENS-CORNING FIBERGLAS CORPORATION (US) | 1992-02-06 | — | — | WO | disclosed |
| WO-1991017136-A1 | CITRATE ESTER COMPOSITIONS AND PROCESSES FOR THEIR PREPARATION | OWENS-CORNING FIBERGLAS CORPORATION (US) | 1991-11-14 | — | — | WO | disclosed |