Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.74 |
| ▸ | HTR2A | P28223 | 3/20 | 0.74 |
| ▸ | HTR2B | P41595 | 3/20 | 0.74 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.74 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.74 |
| ▸ | DRD3 | P35462 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | HTR2C | P28335 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9248064 | 1.00 | SIGMAR1 (0.74) | SIGMAR1HTR2AHTR2BADRA2CSLC6A4 | |
| SCHEMBL9472690 | 1.00 | SIGMAR1 (0.74) | SIGMAR1HTR2AHTR2BADRA2CSLC6A4 | |
| SCHEMBL21632672 | 0.86 | SIGMAR1 (0.85) | SIGMAR1HTR2AHTR2BADRA2CSLC6A4 | |
| Fenfluramine SCHEMBL8196727 | 0.85 | SIGMAR1 (0.94) | SIGMAR1HTR2AHTR2BADRA2CSLC6A4 | |
| Fenfluramine SCHEMBL29447403 | 0.85 | SLC6A4 (1.00) | SIGMAR1HTR2AHTR2BADRA2CSLC6A4 | |
| Fenfluramine SCHEMBL16215 | 0.85 | SLC6A4 (1.00) | SIGMAR1HTR2AHTR2BADRA2CSLC6A4 | |
| Dexfenfluramine SCHEMBL16706 | 0.85 | SLC6A4 (1.00) | SIGMAR1HTR2AHTR2BADRA2CSLC6A4 | |
| Levofenfluramine SCHEMBL29882976 | 0.85 | SLC6A4 (1.00) | SIGMAR1HTR2AHTR2BADRA2CSLC6A4 | |
| Dexfenfluramine SCHEMBL15669714 | 0.85 | SLC6A4 (1.00) | SIGMAR1HTR2AHTR2BADRA2CSLC6A4 | |
| Levofenfluramine SCHEMBL162006 | 0.85 | SLC6A4 (1.00) | SIGMAR1HTR2AHTR2BADRA2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543713-B1 | Ethanolamine benzoate derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-02-22 | — | — | EP | disclosed |
| US-5266591-A | For treatment of abnormal metabolism | ADIR ET COMPAGNIE (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0543713-A1 | Ethanolamine benzoate derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-05-26 | — | — | EP | disclosed |