Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.30 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9156454 | 1.00 | GRM5 (0.36) | GRM5CHRNB2CHRNA2CHRNB4CHRNA3 | |
| SCHEMBL9159140 | 0.96 | CHRNB2 (0.34) | GRM5CHRNB2CHRNA2CHRNB4CHRNA3 | |
| SCHEMBL9159145 | 0.96 | CHRNB2 (0.34) | GRM5CHRNB2CHRNA2CHRNB4CHRNA3 | |
| SCHEMBL9159136 | 0.96 | CHRNB2 (0.34) | GRM5CHRNB2CHRNA2CHRNB4CHRNA3 | |
| SCHEMBL9159155 | 0.96 | CHRNB2 (0.34) | GRM5CHRNB2CHRNA2CHRNB4CHRNA3 | |
| SCHEMBL9155432 | 0.96 | GRM5 (0.36) | GRM5CHRNB2CHRNA2CHRNB4CHRNA3 | |
| SCHEMBL9155426 | 0.96 | GRM5 (0.36) | GRM5CHRNB2CHRNA2CHRNB4CHRNA3 | |
| SCHEMBL9158380 | 0.93 | GRM5 (0.34) | GRM5CHRNB2CHRNA2CHRNB4CHRNA3 | |
| SCHEMBL9158382 | 0.93 | GRM5 (0.34) | GRM5CHRNB2CHRNA2CHRNB4CHRNA3 | |
| SCHEMBL9158386 | 0.93 | GRM5 (0.34) | GRM5CHRNB2CHRNA2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445248-B1 | PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1995-03-08 | — | — | EP | disclosed |
| US-5205962-A | Stable liquid crystals | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-04-27 | — | — | US | disclosed |
| EP-0445248-A1 | PYRIDINE DERIVATIVES. | MERCK PATENT GMBH (DE) | 1991-09-11 | — | — | EP | disclosed |
| WO-1991004248-A1 | PYRIDINE DERIVATIVES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1991-04-04 | — | — | WO | disclosed |