Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9156557 | 1.00 | CHRNB2 (0.42) | CHRNB2CHRNA3CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL9156560 | 1.00 | CHRNB2 (0.42) | CHRNB2CHRNA3CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL9156569 | 1.00 | CHRNB2 (0.42) | CHRNB2CHRNA3CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL9156331 | 0.99 | CHRNB2 (0.41) | CHRNB2CHRNA3CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL9156313 | 0.99 | CHRNB2 (0.41) | CHRNB2CHRNA3CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL9592431 | 0.99 | CHRNB2 (0.41) | CHRNB2CHRNA3CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL9156319 | 0.99 | CHRNB2 (0.41) | CHRNB2CHRNA3CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL9155817 | 0.96 | CHRNB2 (0.43) | CHRNB2CHRNA3CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL9155827 | 0.96 | CHRNB2 (0.43) | CHRNB2CHRNA3CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL9155809 | 0.96 | CHRNB2 (0.43) | CHRNB2CHRNA3CHRNA7CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445248-B1 | PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1995-03-08 | — | — | EP | disclosed |
| US-5205962-A | Stable liquid crystals | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-04-27 | — | — | US | disclosed |
| EP-0445248-A1 | PYRIDINE DERIVATIVES. | MERCK PATENT GMBH (DE) | 1991-09-11 | — | — | EP | disclosed |
| WO-1991004248-A1 | PYRIDINE DERIVATIVES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1991-04-04 | — | — | WO | disclosed |