Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 2/20 | 0.32 |
| ▸ | PLK4 | O00444 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.32 |
| ▸ | PRKCG | P05129 | 2/20 | 0.32 |
| ▸ | ROS1 | P08922 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | AKT2 | P31751 | 2/20 | 0.32 |
| ▸ | MATK | P42679 | 2/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.32 |
| ▸ | BLK | P51451 | 2/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.32 |
| ▸ | NEK4 | P51957 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9155013 | 0.71 | PARP1 (0.45) | PARP1TP53CDC7PLK4MAPK13 | |
| SCHEMBL9155368 | 0.63 | PARP1 (0.43) | PARP1TP53CDC7PLK4MAPK13 | |
| SCHEMBL1133601 | 0.61 | PARP1 (1.00) | PARP1TP53CDC7PLK4MAPK13 | |
| SCHEMBL29673205 | 0.61 | PARP1 (1.00) | PARP1TP53CDC7PLK4MAPK13 | |
| SCHEMBL8569594 | 0.61 | TP53 (0.68) | PARP1TP53CDC7PLK4MAPK13 | |
| SCHEMBL2429766 | 0.61 | PARP1 (0.65) | PARP1TP53CDC7PLK4MAPK13 | |
| SCHEMBL9415441 | 0.61 | PARP1 (0.60) | PARP1TP53CDC7PLK4MAPK13 | |
| SCHEMBL21405585 | 0.60 | PARP1 (0.50) | PARP1TP53CDC7PLK4MAPK13 | |
| SCHEMBL30929174 | 0.60 | PARP1 (0.55) | PARP1TP53CDC7PLK4MAPK13 | |
| SCHEMBL8565857 | 0.59 | PARP1 (0.53) | PARP1TP53CDC7PLK4MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405847-A | Antiallergic, antiasthmatic, anxiolytic, hypotensive agents | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1995-04-11 | — | — | US | disclosed |