Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.40 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.40 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14361434 | 0.81 | PARP1 (0.60) | PARP1TP53DAOMAP4K4TAOK1 | |
| SCHEMBL29673205 | 0.75 | PARP1 (1.00) | PARP1TP53DAOMAP4K4TAOK1 | |
| SCHEMBL1133601 | 0.75 | PARP1 (1.00) | PARP1TP53DAOMAP4K4TAOK1 | |
| SCHEMBL30273115 | 0.72 | PSMB8 (0.40) | PARP1PSMB8DAOMAP4K4TAOK1 | |
| SCHEMBL8569594 | 0.71 | TP53 (0.68) | PARP1TP53MAP4K4TAOK1PBK | |
| SCHEMBL2429766 | 0.71 | PARP1 (0.65) | PARP1TP53DAOMAP4K4TAOK1 | |
| SCHEMBL10503087 | 0.70 | PSMB8 (0.60) | PSMB8DAOGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7276765 | 0.70 | PARP1 (0.69) | PARP1TP53DAOGRIN2DGRIN3B | |
| SCHEMBL8565857 | 0.69 | PARP1 (0.53) | PARP1TP53MAP4K4TAOK1PBK | |
| SCHEMBL30809703 | 0.68 | PDE2A (0.67) | PARP1TP53DAOGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584487-A2 | 4,5-Dihydro-4-oxopyrrolo (1,2-a) quinoxalines and aza-analoges and process for their preparation | ASTA Medica Aktiengesellschaft (DE) | 1994-03-02 | — | — | EP | disclosed |