Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.44 |
| ▸ | RELA | Q04206 | 3/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458244 | 0.93 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL9151939 | 0.90 | RARB (0.45) | SMN1; SMN2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL9152599 | 0.90 | RARB (0.45) | SMN1; SMN2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL9151913 | 0.90 | RARB (0.45) | SMN1; SMN2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL9156669 | 0.90 | RARB (0.45) | SMN1; SMN2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL9156583 | 0.90 | RARB (0.45) | SMN1; SMN2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL9398370 | 0.90 | THRB (0.42) | SMN1; SMN2THRBNPC1NFKB1NFKB2 | |
| SCHEMBL9398302 | 0.90 | THRB (0.42) | SMN1; SMN2THRBNPC1NFKB1NFKB2 | |
| SCHEMBL9398290 | 0.90 | THRB (0.42) | SMN1; SMN2THRBNPC1NFKB1NFKB2 | |
| SCHEMBL9398594 | 0.90 | THRB (0.42) | SMN1; SMN2THRBNPC1NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5407599-A | Cyclopropylaklyl or -alkenyl or heterocyclic compounds, process for their preparation and their use in liquid-crystalline mixtures | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-04-18 | — | — | US | disclosed |