Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 3/20 | 0.76 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | MAOB | P27338 | 3/20 | 0.58 |
| ▸ | EP300 | Q09472 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9158175 | 0.86 | NR4A2 (0.66) | CREBBPNR4A2SRCRAB9AMAOB | |
| SCHEMBL28624532 | 0.86 | CREBBP (1.00) | CREBBPSRCRAB9AEP300 | |
| SCHEMBL6005094 | 0.82 | MAOB (0.61) | CREBBPNR4A2MAOBEP300ALDH1A1 | |
| SCHEMBL4811502 | 0.81 | MAOB (0.84) | CREBBPNR4A2RAB9AMAOBEP300 | |
| SCHEMBL29176621 | 0.81 | MAOB (0.62) | CREBBPNR4A2MAOBEP300ALDH1A1 | |
| SCHEMBL9163212 | 0.78 | NR4A2 (0.72) | NR4A2SRCRAB9ATSHRALDH1A1 | |
| SCHEMBL31621504 | 0.77 | NR4A2 (1.00) | NR4A2TSHRALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL1092934 | 0.77 | NR4A2 (1.00) | NR4A2TSHRALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL9165197 | 0.76 | EGFR (0.57) | CREBBPNR4A2SRCMAOBEP300 | |
| SCHEMBL677770 | 0.76 | RAB9A (1.00) | RAB9AALDH1A1SMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5464861-A | Anticarcinogenic agents | WARNER-LAMBERT (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0654024-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003427-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |