Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9166566 | 0.88 | MAPT (0.43) | MAPTNPBWR1KMT2AMEN1NPSR1 | |
| SCHEMBL9159768 | 0.88 | MAPT (0.43) | MAPTHSD17B10NPBWR1KMT2AMEN1 | |
| SCHEMBL27295882 | 0.84 | MAPT (0.41) | MAPTKMT2AMEN1NPSR1SMN1; SMN2 | |
| SCHEMBL9159424 | 0.83 | MEN1 (0.42) | MAPTHSD17B10NPBWR1KMT2AMEN1 | |
| SCHEMBL9136565 | 0.81 | HSD17B10 (0.37) | MAPTHSD17B10NPBWR1KMT2AMEN1 | |
| SCHEMBL26199343 | 0.78 | MAPT (0.49) | MAPTKMT2AMEN1NPSR1SMN1; SMN2 | |
| SCHEMBL9158219 | 0.77 | LCK (0.43) | MAPTKMT2AMEN1SMN1; SMN2CYP3A4 | |
| SCHEMBL9159576 | 0.76 | MAPT (0.40) | MAPTHSD17B10NPBWR1KMT2AMEN1 | |
| SCHEMBL1024702 | 0.75 | MAPT (0.47) | MAPTKMT2AMEN1NPSR1SMN1; SMN2 | |
| SCHEMBL1025814 | 0.75 | MAPT (0.48) | MAPTHSD17B10KMT2AMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354994-B1 | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5254565-A | Enzyme inhibitors; anticholesterol agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-19 | — | — | US | disclosed |
| EP-0354994-A2 | Quinoline derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-02-21 | — | — | EP | disclosed |