Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | MAP2 | P11137 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9159295 | 0.88 | MAPT (0.45) | MAPTLMNAALDH1A1CYP3A4NPSR1 | |
| SCHEMBL9162530 | 0.85 | SMN1; SMN2 (0.49) | MAPTGFERHSD11B1POLBLMNA | |
| SCHEMBL9161177 | 0.85 | PIN1 (0.47) | MAPTGFERMAP2LMNAALDH1A1 | |
| SCHEMBL9163285 | 0.85 | PDE7A (0.40) | MAPTGFERHSD11B1POLBLMNA | |
| SCHEMBL27287793 | 0.82 | PRKCQ (0.40) | MAPTGFERHSD11B1POLBLMNA | |
| SCHEMBL9163305 | 0.81 | KMT2A (0.40) | MAPTGFERHSD11B1POLBLMNA | |
| SCHEMBL9166566 | 0.81 | MAPT (0.43) | MAPTHSD11B1LMNAALDH1A1CYP3A4 | |
| SCHEMBL9164509 | 0.80 | GRM5 (0.46) | MAPTGFERPOLBALDH1A1CYP3A4 | |
| SCHEMBL9248753 | 0.79 | TSHR (0.42) | MAPTGFERLMNAALDH1A1CYP3A4 | |
| SCHEMBL9159576 | 0.79 | MAPT (0.40) | MAPTHSD11B1POLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354994-B1 | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5254565-A | Enzyme inhibitors; anticholesterol agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-19 | — | — | US | disclosed |
| EP-0354994-A2 | Quinoline derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-02-21 | — | — | EP | disclosed |