Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.55 |
| ▸ | LPAR3 | Q9UBY5 | 5/20 | 0.55 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.55 |
| ▸ | LPAR6 | P43657 | 3/20 | 0.55 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.55 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | PRKCG | P05129 | 1/20 | 0.53 |
| ▸ | PRKCB | P05771 | 1/20 | 0.53 |
| ▸ | PRKCA | P17252 | 1/20 | 0.53 |
| ▸ | PRKCH | P24723 | 1/20 | 0.53 |
| ▸ | PRKCI | P41743 | 1/20 | 0.53 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.53 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.53 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.53 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10547478 | 0.91 | LPAR1 (0.60) | LPAR1LPAR3LPAR5LPAR6LPAR4 | |
| SCHEMBL404985 | 0.89 | HTT (0.52) | LPAR1LPAR3LPAR5LPAR6LPAR4 | |
| SCHEMBL29091228 | 0.89 | HTT (0.52) | LPAR1LPAR3LPAR5LPAR6LPAR4 | |
| SCHEMBL13421650 | 0.87 | TSHR (0.48) | LPAR1LPAR3LPAR5LPAR6LPAR4 | |
| SCHEMBL7919814 | 0.85 | LMNA (0.56) | LPAR1LPAR3LPAR5LPAR6LPAR4 | |
| SCHEMBL16636591 | 0.85 | LMNA (0.56) | LPAR1LPAR3LPAR5LPAR6LPAR4 | |
| SCHEMBL8844487 | 0.85 | LMNA (0.56) | LPAR1LPAR3LPAR5LPAR6LPAR4 | |
| SCHEMBL10554878 | 0.83 | MEN1 (0.55) | LPAR1LPAR3LPAR5LPAR6LPAR4 | |
| SCHEMBL1556424 | 0.83 | SMN1; SMN2 (0.55) | LPAR1LPAR3LPAR5LPAR6LPAR4 | |
| SCHEMBL12200017 | 0.83 | PRKD3 (0.46) | LPAR1LPAR3LPAR5LPAR6LPAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5411983-A | Certain hyrdoxy-phosphinyl-oxy-phenylmethyl-imidazolium hydroxide inner salts as PAF antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-05-02 | — | — | US | disclosed |
| US-5234918-A | For cardiovascular, respiratory, carcinogenic and inflammatory disorders | AMERICAN CYANAMID COMPANY (US) | 1993-08-10 | — | — | US | disclosed |
| US-5215975-A | Certain hydroxy-phosphinyl-oxy-phenyl methyl-thiazolium hydroxide inner salts as PAF antagonists | AMERICAN CYANAMID COMPANY (US) | 1993-06-01 | — | — | US | disclosed |
| EP-0336142-A2 | Novel antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1989-10-11 | — | — | EP | disclosed |