SCHEMBL9162471

SCHEMBL9162471

OCC(c1ccccc1)(c1ccccc1)C1CCCN1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 4/20 0.61
CYP1A2 P05177 3/20 0.61
CYP2C19 P33261 2/20 0.61
KDM4E B2RXH2 1/20 0.61
NPC1 O15118 1/20 0.61
HPGD P15428 1/20 0.61
MAPK1 P28482 1/20 0.61
RAB9A P51151 1/20 0.61
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
LMNA P02545 2/20 0.38
HRH1 P35367 1/20 0.38
SCN1A P35498 1/20 0.38
SCN2A Q99250 1/20 0.38
SCN3A Q9NY46 1/20 0.38
POLB P06746 1/20 0.37
TACR1 P25103 3/20 0.36
TP53 P04637 2/20 0.36
CYP3A4 P08684 2/20 0.36
TSHR P16473 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9162459 1.00 CYP2D6 (0.61) CYP2D6CYP1A2CYP2C19KDM4ENPC1
SCHEMBL17676876 0.80 CYP2D6 (0.56) CYP2D6CYP1A2CYP2C19KDM4ENPC1
SCHEMBL239738 0.77 CYP2D6 (0.96) CYP2D6CYP1A2CYP2C19KDM4ENPC1
SCHEMBL100361 0.77 CYP2D6 (0.96) CYP2D6CYP1A2CYP2C19KDM4ENPC1
SCHEMBL100360 0.77 CYP2D6 (0.96) CYP2D6CYP1A2CYP2C19KDM4ENPC1
SCHEMBL18609239 0.77 CYP2D6 (0.54) CYP2D6CYP1A2CYP2C19KDM4ENPC1
SCHEMBL10327130 0.77 CYP2D6 (0.66) CYP2D6CYP1A2CYP2C19KDM4ENPC1
SCHEMBL10326880 0.77 CYP2D6 (0.66) CYP2D6CYP1A2CYP2C19KDM4ENPC1
SCHEMBL10326636 0.77 CYP2D6 (0.66) CYP2D6CYP1A2CYP2C19KDM4ENPC1
SCHEMBL8136171 0.76 CYP2D6 (0.93) CYP2D6CYP1A2CYP2C19KDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0305180-B1 Enantioselective reduction of ketones HARVARD COLLEGE (US) 1995-03-22 EP disclosed
US-4943635-A OXAZABOROLIDINES AND OXAZABORINES AS CATALYSTS PRESIDENT & FELLOWS OF HARVARD COLLEGE (US) 1990-07-24 US disclosed
EP-0305180-A2 Enantioselective reduction of ketones THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1989-03-01 EP disclosed