⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7858273 | 0.70 | — | — | |
| SCHEMBL2487632 | 0.65 | — | — | |
| SCHEMBL17824477 | 0.65 | — | — | |
| SCHEMBL27912626 | 0.65 | — | — | |
| SCHEMBL28063195 | 0.65 | — | — | |
| SCHEMBL11614207 | 0.61 | — | — | |
| SCHEMBL595526 | 0.61 | — | — | |
| SCHEMBL4992008 | 0.60 | — | — | |
| SCHEMBL27543334 | 0.60 | — | — | |
| SCHEMBL440610 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053590-A | A method of preparing the chloro- 2- aminopyrimidine of 4,6- bis- | 江苏富鼎化学有限公司 | 2018-12-21 | — | — | CN | claimed |
| CN-109734674-A | Phenyl amines WDR5 protein-protein interaction inhibitor and its preparation method and purposes | 中国药科大学 | 2019-05-10 | — | — | CN | disclosed |
| CN-109232402-A | A kind of preparation method for the nitrogenous hexa-member heterocycle class compound that 2- amino replaces | 五邑大学 | 2019-01-18 | — | — | CN | disclosed |
| CN-109053590-A | A method of preparing the chloro- 2- aminopyrimidine of 4,6- bis- | 江苏富鼎化学有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-109053590-A | A method of preparing the chloro- 2- aminopyrimidine of 4,6- bis- | 江苏富鼎化学有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-109053590-A | A method of preparing the chloro- 2- aminopyrimidine of 4,6- bis- | 江苏富鼎化学有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-103917528-B | PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-04-20 | — | — | CN | disclosed |
| CN-105392788-A | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC | 2016-03-09 | — | — | CN | disclosed |
| CN-103917528-A | Pyrimidine PDE10 inhibitors | MERCK SHARP & DOHME | 2014-07-09 | — | — | CN | disclosed |
| EP-0644885-A1 | NOVEL BIOLOGICALLY ACTIVE EBURNAMENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | RICHETER GEDEON VEGYESZETI GYAR RT. (HU) | 1995-03-29 | — | — | EP | disclosed |