Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | ACE | P12821 | 10/20 | 0.50 |
| ▸ | REN | P00797 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PEPD | P12955 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9162445 | 1.00 | LMNA (0.64) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL2636385 | 0.85 | LMNA (0.68) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL3189885 | 0.85 | LMNA (0.68) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL11993551 | 0.85 | LMNA (0.68) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL31732283 | 0.82 | LMNA (0.64) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL29876707 | 0.82 | LMNA (0.64) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL9392063 | 0.82 | LMNA (0.69) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL7321336 | 0.82 | LMNA (0.69) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL9392071 | 0.82 | LMNA (0.69) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL24339739 | 0.80 | LMNA (0.61) | LMNAHSD17B10CYP2C19ACEREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5424454-A | 2,2,-dichloropropionyl-L-proline | CELGENE CORPORATION (US) | 1995-06-13 | — | — | US | disclosed |
| WO-1994026771-A1 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF L-ALANYL-L-PROLINE | CELGENE CORPORATION (US) | 1994-11-24 | — | — | WO | disclosed |
| US-5319098-A | Hydrogenating an N-(1-iminoethylcarbonyl)proline using a metal hydrogenolysis catalyst and a pH of less than 4 | CELGENE CORPORATION (US) | 1994-06-07 | — | — | US | disclosed |