Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545291 | 0.89 | PARP1 (0.43) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL9378774 | 0.89 | PARP1 (0.43) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8540141 | 0.89 | PARP1 (0.43) | PARP1GSK3BMAPTHTTGPR84 | |
| SCHEMBL9423361 | 0.88 | PARP1 (0.42) | PARP1GSK3BMAPTHTTGPR84 | |
| SCHEMBL9305376 | 0.88 | PARP1 (0.42) | PARP1GSK3BMAPTHTTGPR84 | |
| SCHEMBL9307919 | 0.87 | RAD52 (0.43) | PARP1GSK3BMAPTHTTGPR84 | |
| SCHEMBL9052175 | 0.84 | MAPT (0.59) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8538920 | 0.83 | PARP1 (0.45) | PARP1GSK3BMAPTHTTGABRA1 | |
| SCHEMBL9374556 | 0.83 | GSK3B (0.39) | KDM4EALDH1A1PARP1GSK3BMAPT | |
| SCHEMBL9373258 | 0.81 | PARP1 (0.43) | KDM4EPARP1GSK3BMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1037440-C | Angiotensin II Receptor blocking 2,3,6 substituted quinazolinones | AMERICAL CYANAMID CO (US) | 1998-02-18 | — | — | CN | disclosed |
| US-5405849-A | Treating hypertension, congestive heart failure | AMERICAN CYANAMID COMPANY (US) | 1995-04-11 | — | — | US | disclosed |
| US-5290780-A | Hypotensive agents; congestive heart failure | AMERICAN CYANAMID CO. (US) | 1994-03-01 | — | — | US | disclosed |
| CN-1066847-A | Angiotensin-ii receptor blockers 2,3,6 quinazolinones that replace | AMERICAN CYANAMID CO (US) | 1992-12-09 | — | — | CN | disclosed |