Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8009140 | 0.84 | EPHX2 (0.47) | EPHX2DDB1CRBNGAAHDAC2 | |
| SCHEMBL28757730 | 0.84 | EPHX2 (0.47) | EPHX2DDB1CRBNGAAHDAC2 | |
| SCHEMBL840894 | 0.84 | EPHX2 (0.47) | EPHX2DDB1CRBNGAAHDAC2 | |
| SCHEMBL20189142 | 0.84 | EPHX2 (0.47) | EPHX2DDB1CRBNGAAHDAC2 | |
| SCHEMBL9850086 | 0.83 | DDB1 (0.69) | EPHX2DDB1CRBNGAAHDAC2 | |
| SCHEMBL1011633 | 0.83 | DDB1 (0.69) | EPHX2DDB1CRBNGAAHDAC2 | |
| SCHEMBL9850110 | 0.81 | DDB1 (0.67) | EPHX2DDB1CRBNGAAHDAC2 | |
| SCHEMBL15038459 | 0.81 | ERCC1 (0.54) | DDB1CRBNGAAERCC1ERCC4 | |
| SCHEMBL2001787 | 0.81 | ENPP2 (0.57) | EPHX2DDB1CRBNGAAHDAC2 | |
| SCHEMBL22144492 | 0.80 | EPHX2 (0.47) | EPHX2DDB1CRBNGAAHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436260-A | Substituted 1-benzylimidazole-5-methylidene hydantoins | WARNER-LAMBERT COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| US-5308853-A | Hypotensive agents, antagonists of angiotensin II | WARNER-LAMBERT COMPANY (US) | 1994-05-03 | — | — | US | disclosed |
| WO-1993013077-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1993-07-08 | — | — | WO | disclosed |