Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226114 | 0.78 | SMN1; SMN2 (0.41) | KMT2AMEN1SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL1201738 | 0.78 | AKR1B1 (0.60) | AKR1B1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL9167885 | 0.77 | AKR1B1 (0.53) | AKR1B1KMT2AMEN1NPC1TDP1 | |
| SCHEMBL9163190 | 0.76 | AKR1B1 (0.61) | AKR1B1KMT2AMEN1NPC1TDP1 | |
| SCHEMBL7089003 | 0.75 | KMT2A (0.53) | AKR1B1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL12323598 | 0.74 | KMT2A (0.67) | AKR1B1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL5623718 | 0.73 | CYP1A2 (0.65) | AKR1B1KMT2AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL7088124 | 0.73 | KMT2A (0.59) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9711302 | 0.71 | TDP1 (0.47) | NPC1RAB9ASMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL7085104 | 0.70 | KMT2A (0.51) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430060-A | Aldose reductase inhibitor | ZENECA LIMITED (GB) | 1995-07-04 | — | — | US | disclosed |
| EP-0469887-B1 | Acetamide derivatives | ZENECA LTD (GB) | 1994-12-14 | — | — | EP | disclosed |
| US-5270342-A | Acetamide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-14 | — | — | US | disclosed |
| EP-0469887-A1 | Acetamide derivatives | ZENECA LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |