Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | SCN4A | P35499 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740362 | 0.82 | TSHR (0.37) | TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL7229176 | 0.77 | MAPT (0.38) | TDP1ALDH1A1TSHRSMN1; SMN2POLB | |
| SCHEMBL9711236 | 0.77 | TDP1 (0.40) | TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL7226114 | 0.70 | SMN1; SMN2 (0.41) | TDP1ALDH1A1SMN1; SMN2HSD17B10GAA | |
| SCHEMBL9711273 | 0.69 | KMT2A (0.37) | TDP1ALDH1A1TSHRSMN1; SMN2L3MBTL1 | |
| SCHEMBL20801750 | 0.69 | SCN4A (0.50) | ALDH1A1TSHRSMN1; SMN2SCN4AL3MBTL1 | |
| SCHEMBL4368896 | 0.68 | ALDH1A1 (0.48) | TDP1ALDH1A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL31474641 | 0.68 | TDP1 (0.52) | TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL9353183 | 0.68 | PDE7A (0.36) | TDP1ALDH1A1SMN1; SMN2L3MBTL1HPGD | |
| SCHEMBL9739997 | 0.68 | LMNA (0.41) | TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153227-A | Treatment of diabetes and galactosemia complications | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | disclosed |
| EP-0304190-B1 | (ARYLSULPHONYL)NITROMETHANES, PROCESS FOR THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-08 | — | — | EP | disclosed |
| EP-0304190-A1 | (Arylsulphonyl)nitromethanes, process for their preparation and use in pharmaceutical compositions | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-02-22 | — | — | EP | disclosed |