Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30598667 | 0.98 | SIGMAR1 (0.35) | SIGMAR1OPRD1SLC6A4LMNACHRM5 | |
| SCHEMBL9158636 | 0.98 | SIGMAR1 (0.37) | SIGMAR1OPRD1SLC6A4LMNACHRM5 | |
| SCHEMBL9161735 | 0.98 | SIGMAR1 (0.37) | SIGMAR1OPRD1SLC6A4LMNACHRM5 | |
| SCHEMBL9167411 | 0.96 | SIGMAR1 (0.38) | SIGMAR1OPRD1SLC6A4LMNACHRM5 | |
| SCHEMBL30598663 | 0.94 | SIGMAR1 (0.37) | SIGMAR1OPRD1SLC6A4LMNACHRM5 | |
| SCHEMBL300399 | 0.85 | — | — | |
| SCHEMBL8310688 | 0.84 | SIGMAR1 (0.41) | SIGMAR1OPRD1SLC6A4LMNACHRM5 | |
| SCHEMBL6423819 | 0.83 | SIGMAR1 (0.41) | SIGMAR1OPRD1SLC6A4CHRM5CHRM3 | |
| SCHEMBL31492641 | 0.82 | SIGMAR1 (0.39) | SIGMAR1OPRD1CHRM5CHRM3CA2 | |
| SCHEMBL30914551 | 0.81 | HSD17B10 (0.37) | SIGMAR1OPRD1SLC6A4LMNACHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0325762-B1 | Macrocyclic chelating agents and chelates thereof | BRACCO SPA (IT) | 1995-03-22 | — | — | EP | claimed |
| EP-0325762-A1 | Macrocyclic chelating agents and chelates thereof | BRACCO S.p.A. (IT) | 1989-08-02 | — | — | EP | claimed |
| EP-0325762-B1 | Macrocyclic chelating agents and chelates thereof | BRACCO SPA (IT) | 1995-03-22 | — | — | EP | disclosed |
| US-5132409-A | Derivatives of 1,4,7,10-Tetraazacyclododecane | BRACCO INDUSTRIA CHIMICA S.P.A. (IT) | 1992-07-21 | — | — | US | disclosed |
| EP-0325762-A1 | Macrocyclic chelating agents and chelates thereof | BRACCO S.p.A. (IT) | 1989-08-02 | — | — | EP | disclosed |