Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ESRRA | P11474 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | STK4 | Q13043 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8086098 | 0.87 | KDM4E (0.45) | KMT2AMAPTGAAALDH1A1KDM4E | |
| Trifluoromethanesulfonic Acid SCHEMBL11085448 | 0.87 | PTPN1 (0.40) | KMT2AMAPTGAAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9167304 | 0.82 | MAPT (0.43) | KMT2AMAPTGAAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL11120185 | 0.81 | PTPN1 (0.43) | KMT2AMAPTGAAALDH1A1KDM4E | |
| SCHEMBL13706522 | 0.80 | MAPT (0.43) | KMT2AMAPTGAAALDH1A1KDM4E | |
| Bromide SCHEMBL9163098 | 0.79 | MAPT (0.43) | KMT2AMAPTALDH1A1KDM4ECYP3A4 | |
| Hydrochloric Acid SCHEMBL1785872 | 0.78 | MAPT (0.67) | KMT2AMAPTGAAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9497972 | 0.77 | MAPT (0.65) | KMT2AMAPTGAAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9818222 | 0.77 | MAPT (0.65) | KMT2AMAPTGAAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL8414465 | 0.77 | MAPT (0.65) | KMT2AMAPTGAAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0428362-B1 | Photosensitive resin and element made therefrom | HOECHST CELANESE CORP (US) | 1995-04-19 | — | — | EP | disclosed |
| EP-0326714-B1 | Three dimensional light-sensitive diazonium condensates | HOECHST CELANESE CORP (US) | 1994-01-19 | — | — | EP | disclosed |
| US-5200291-A | Photosensitive diazonium resin, element made therefrom, method of preparing the resin and method for producing negative lithographic image utilizing the resin | HOECHST CELANESE CORPORATION (US) | 1993-04-06 | — | — | US | disclosed |
| EP-0428362-A1 | Photosensitive resin and element made therefrom | HOECHST CELANESE CORPORATION (US) | 1991-05-22 | — | — | EP | disclosed |
| US-4914000-A | Three dimensional reproduction material diazonium condensates and use in light sensitive | HOECHST CELANESE CORPORATION (US) | 1990-04-03 | — | — | US | disclosed |
| EP-0326714-A2 | Three dimensional light-sensitive diazonium condensates | HOECHST CELANESE CORPORATION (US) | 1989-08-09 | — | — | EP | disclosed |
| US-4436804-A | Light-sensitive polymeric diazonium condensates and reproduction compositions and materials therewith | AMERICAN HOECHST CORPORATION (US) | 1984-03-13 | — | — | US | disclosed |