Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9159818 | 0.91 | P2RY14 (0.40) | P2RY14NR1H4MAPTEPHX2THRB | |
| Hydrochloric Acid SCHEMBL9169356 | 0.91 | MAPT (0.46) | MAPTTHRBFAAH | |
| Hydrochloric Acid SCHEMBL9167427 | 0.87 | KCNJ5 (0.39) | P2RY14MAPTEPHX2KCNJ5KCNJ3 | |
| Hydrochloric Acid SCHEMBL9160754 | 0.87 | KCNJ5 (0.39) | P2RY14MAPTEPHX2KCNJ5KCNJ3 | |
| Hydrochloric Acid SCHEMBL9164136 | 0.87 | P2RY14 (0.54) | P2RY14NR1H4MAPTLMNA | |
| Hydrochloric Acid SCHEMBL9161430 | 0.87 | P2RY14 (0.54) | P2RY14NR1H4MAPTLMNA | |
| Hydrochloric Acid SCHEMBL9168981 | 0.87 | EPHX2 (0.42) | P2RY14MAPTEPHX2LMNA | |
| Hydrochloric Acid SCHEMBL9165072 | 0.87 | EPHX2 (0.42) | P2RY14MAPTEPHX2LMNA | |
| Hydrochloric Acid SCHEMBL9167299 | 0.86 | CNR1 (0.44) | P2RY14MAPTLMNA | |
| Hydrochloric Acid SCHEMBL9870998 | 0.86 | CNR1 (0.44) | P2RY14MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432189-A | Bis-aryl amide and urea antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1995-07-11 | — | — | US | disclosed |
| US-5350759-A | Bis-aryl urea compounds | WISSNER ALLAN (US) | 1994-09-27 | — | — | US | disclosed |
| US-5231182-A | Platelet activating factor inhibitor | AMERICAN CYANAMID COMPANY (US) | 1993-07-27 | — | — | US | disclosed |
| US-5225425-A | Respiratory system disorders | AMERICAN CYANAMID COMPANY (US) | 1993-07-06 | — | — | US | disclosed |
| US-5128351-A | BIS-ARYL AMIDE AND UREA ANTAGONISTS OF PLATELET ACTIVATING FACTOR | AMERICAN CYANAMID COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
| US-5077409-A | Reducing hydroxy bis-aryl amide, acylating, hydrolyzing, sulfonating, halogenating, alkylating with nitrogen heterocycle | AMERICAN CYANAMID COMPANY (US) | 1991-12-31 | — | — | US | disclosed |