Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 11/20 | 0.69 |
| ▸ | RXRB | P28702 | 9/20 | 0.69 |
| ▸ | RXRG | P48443 | 7/20 | 0.69 |
| ▸ | RARB | P10826 | 10/20 | 0.68 |
| ▸ | RARG | P13631 | 9/20 | 0.68 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.65 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.65 |
| ▸ | RARA | P10276 | 7/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9551753 | 0.91 | RXRA (0.57) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9175151 | 0.91 | RXRA (0.74) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9698293 | 0.89 | RXRA (0.66) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9551765 | 0.88 | RXRA (0.54) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9595211 | 0.88 | RARB (0.60) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9551723 | 0.87 | PARP10 (0.53) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL5084209 | 0.86 | RXRA (0.66) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9551735 | 0.85 | RXRA (0.55) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9551760 | 0.85 | RARB (0.52) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9551756 | 0.85 | CYP3A4 (0.58) | RXRARXRBRXRGRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642499-A1 | RETINOIDS AND THEIR USE IN TREATING SKIN DISEASES AND LEUKEMIA | PFIZER INC. (US) | 1995-03-15 | — | — | EP | claimed |
| WO-1993006086-A1 | RETINOIDS AND THEIR USE IN TREATING SKIN DISEASES AND LEUKEMIA | PFIZER INC. (US) | 1993-04-01 | — | — | WO | claimed |
| EP-0337689-B1 | TETRALIN ESTERS OF PHENOLS OR BENZOIC ACIDS HAVING RETINOID LIKE ACTIVITY | ALLERGAN, INC (US) | 1993-03-10 | — | — | EP | claimed |
| US-5130335-A | Treatment of skin disorders | ALLERGAN, INC. (US) | 1992-07-14 | — | — | US | claimed |
| EP-0337689-A1 | Tetralin esters of phenols or benzoic acids having retinoid like activity | ALLERGAN, INC (US) | 1989-10-18 | — | — | EP | claimed |
| EP-0642499-A1 | RETINOIDS AND THEIR USE IN TREATING SKIN DISEASES AND LEUKEMIA | PFIZER INC. (US) | 1995-03-15 | — | — | EP | disclosed |
| US-5231113-A | Skin disorders, immunology or wound healing agents | ALLERGAN, INC. (US) | 1993-07-27 | — | — | US | disclosed |
| WO-1993006086-A1 | RETINOIDS AND THEIR USE IN TREATING SKIN DISEASES AND LEUKEMIA | PFIZER INC. (US) | 1993-04-01 | — | — | WO | disclosed |
| EP-0337689-B1 | TETRALIN ESTERS OF PHENOLS OR BENZOIC ACIDS HAVING RETINOID LIKE ACTIVITY | ALLERGAN, INC (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5130335-A | Treatment of skin disorders | ALLERGAN, INC. (US) | 1992-07-14 | — | — | US | disclosed |
| EP-0337689-A1 | Tetralin esters of phenols or benzoic acids having retinoid like activity | ALLERGAN, INC (US) | 1989-10-18 | — | — | EP | disclosed |