⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473714 | 0.76 | TAS1R3 (0.34) | — | |
| SCHEMBL1191168 | 0.74 | — | — | |
| SCHEMBL230050 | 0.74 | CA12 (0.35) | — | |
| SCHEMBL20274815 | 0.73 | — | — | |
| SCHEMBL20274818 | 0.73 | — | — | |
| SCHEMBL7307235 | 0.73 | — | — | |
| SCHEMBL7423921 | 0.71 | HSD17B10 (0.44) | — | |
| SCHEMBL1937505 | 0.70 | — | — | |
| SCHEMBL14584364 | 0.70 | — | — | |
| SCHEMBL18690828 | 0.70 | CYP2D6 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230331717-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | KUMQUAT BIOSCIENCES INC. | 2023-10-19 | — | — | US | disclosed |
| CN-106660971-B | Dual inhibitor compounds for use in the treatment of neurodegenerative diseases and alzheimer's disease | 意大利学院科技基金会 | 2020-10-13 | — | — | CN | disclosed |
| US-9975861-B2 | Dual inhibitor compounds for use in the treatment of neurodegenerative disorders and alzheimer's disease | FONDAZIONE ISTITUTO ITAIANO DI TECNOLOGIA (IT) | 2018-05-22 | — | — | US | disclosed |
| EP-3154953-B1 | DUAL INHIBITOR COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS AND ALZHEIMER'S DISEASE | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2018-04-04 | — | — | EP | disclosed |
| US-20170096406-A1 | Dual Inhibitor Compounds for Use in the Treatment of Neurodegenerative Disorders and Alzheimer's Disease | ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA (IT) | 2017-04-06 | — | — | US | disclosed |
| US-8063057-B2 | Multicyclic amino acid derivatives and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-7875622-B2 | administering to a patient A therapeutically effective amounts of an endothelin receptor antagonist e.g. ambrisentan, bosentan etc. and (S)-2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-methoxybiphenyl-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid to treat pulmonary hypertension | LEXICON PHARMACEUTICALS, INC. (US) | 2011-01-25 | — | — | US | disclosed |
| US-20100317664-A1 | METHODS OF AFFECTING GASTROINTESTINAL TRANSIT AND GASTRIC EMPTYING, AND COMPOUNDS USEFUL THEREIN | LEXICON PHARMACEUTICALS, INC. | 2010-12-16 | — | — | US | disclosed |
| US-20100280054-A1 | MULTICYCLIC AMINO ACID DERIVATIVES AND METHODS OF THEIR USE | TERSERA THERAPEUTICS LLC | 2010-11-04 | — | — | US | disclosed |
| US-7723345-B2 | Multicyclic amino acid derivatives and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2010-05-25 | — | — | US | disclosed |
| EP-0079554-A2 | Polymethylene fibrids, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-05-25 | — | — | EP | disclosed |
| EP-0000765-B1 | PROCESS FOR THE PREPARATION OF GRANULAR OXYMETHYLENE POLYMERS HAVING IMPROVED MECHANICAL PROPERTIES | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-06-17 | — | — | EP | disclosed |
| US-4195158-A | PRECIPITATION FROM METHANOL-WATER MIXTURE; ENGINEERING PLASTICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-03-25 | — | — | US | disclosed |
| US-4151346-A | Process for preparing oxymethylene polymers in a granular form | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-04-24 | — | — | US | disclosed |
| EP-0000765-A1 | Process for the preparation of granular oxymethylene polymers having improved mechanical properties | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-02-21 | — | — | EP | disclosed |
| US-4111912-A | PROCESS FOR THE MANUFACTURE OF COARSE-GRANULAR OXYMETHYLENE POLYMERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4082729-A | PROCESS FOR THE PREPARATION OF OXYMETHYLENE POLYMERS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-04-04 | — | — | US | disclosed |
| US-4046738-A | TWO-STAGE COOLING TO JUST BELOW SINTERING TEMPERATURE | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-09-06 | — | — | US | disclosed |
| US-3996232-A | ANTIULCER AGENTS | WILLIAM H. RORER, INC. (US) | 1976-12-07 | — | — | US | disclosed |
| US-3969292-A | Stabilized molding compositions based on poly(oxymethylene) | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-07-13 | — | — | US | disclosed |