Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.39 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KCNJ6 | P48051 | 3/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9173515 | 0.95 | KCNJ6 (0.42) | CCNA2CDK2CCNA1PIK3CDPIK3R2 | |
| SCHEMBL8135900 | 0.91 | CCNA2 (0.37) | CCNA2CDK2CCNA1MAPK13MAPK12 | |
| SCHEMBL9174895 | 0.91 | CCNA2 (0.40) | CCNA2CDK2CCNA1PIK3CDPIK3R2 | |
| SCHEMBL9167950 | 0.91 | RIPK1 (0.37) | CCNA2CDK2CCNA1MAPK13MAPK12 | |
| SCHEMBL9171530 | 0.91 | RIPK1 (0.41) | KCNJ6KCNJ3KCNJ5NPC1RAB9A | |
| SCHEMBL9171526 | 0.90 | MAPK13 (0.41) | MAPK13MAPK12MAPK11MAPK14PIK3CD | |
| SCHEMBL9170088 | 0.90 | CCNA2 (0.41) | CCNA2CDK2CCNA1PIK3CDPIK3R2 | |
| SCHEMBL9176690 | 0.90 | PIK3CD (0.39) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9176056 | 0.90 | CNR2 (0.40) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9170069 | 0.88 | PIK3CD (0.41) | CCNA2CDK2CCNA1PIK3CDPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5424308-A | Immunomodulating agents | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-06-13 | — | — | US | disclosed |
| EP-0422051-A1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012630-A1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347773-A1 | Condensed Pyrazole 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1989-12-27 | — | — | EP | disclosed |