Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 13/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9182057 | 1.00 | SPHK1 (0.43) | SPHK1SPHK2P2RY14HDAC2 | |
| SCHEMBL9182052 | 1.00 | SPHK1 (0.43) | SPHK1SPHK2P2RY14HDAC2 | |
| SCHEMBL9773969 | 0.96 | SPHK1 (0.46) | SPHK1SPHK2HDAC2 | |
| SCHEMBL9773985 | 0.96 | SPHK1 (0.46) | SPHK1SPHK2HDAC2 | |
| SCHEMBL9773979 | 0.96 | SPHK1 (0.46) | SPHK1SPHK2HDAC2 | |
| SCHEMBL9773993 | 0.96 | SPHK1 (0.46) | SPHK1SPHK2HDAC2 | |
| SCHEMBL8454730 | 0.91 | SPHK1 (0.40) | SPHK1SPHK2P2RY14HDAC2 | |
| SCHEMBL8454718 | 0.91 | SPHK1 (0.40) | SPHK1SPHK2P2RY14HDAC2 | |
| SCHEMBL8454728 | 0.91 | SPHK1 (0.40) | SPHK1SPHK2P2RY14HDAC2 | |
| SCHEMBL8454713 | 0.91 | SPHK1 (0.40) | SPHK1SPHK2P2RY14HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0464648-B1 | 4-Cyano-3-fluorophenyl esters | HOFFMANN LA ROCHE (CH) | 1995-12-06 | — | — | EP | disclosed |
| US-5454974-A | Halobenzene liquid crystals | HOFFMANN-LA ROCHE INC. (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0457105-B1 | Chiral dioxanes as components of liquid crystal mixtures | HOFFMANN LA ROCHE (CH) | 1995-07-26 | — | — | EP | disclosed |
| US-5413734-A | 4-cyano-3-fluorophenyl esters | HOFFMANN-LA ROCHE INC. (US) | 1995-05-09 | — | — | US | disclosed |
| US-5302317-A | Halobenzene liquid crystals | HOFFMANN-LA ROCHE INC. (US) | 1994-04-12 | — | — | US | disclosed |
| EP-0355552-B1 | Alkoxymethyl- and alkenyloxymethyl-cyclohexanes | HOFFMANN LA ROCHE (CH) | 1994-02-23 | — | — | EP | disclosed |
| US-5230826-A | HALOBENZENE LIQUID CRYSTALS | HOFFMANN-LA ROCHE INC. (US) | 1993-07-27 | — | — | US | disclosed |
| US-5185098-A | Liquid crystalline mixtures containing 3,4-difluorophenyl-substituted bicyclohexyls | HOFFMANN-LA ROCHE INC. (US) | 1993-02-09 | — | — | US | disclosed |
| EP-0464648-A1 | 4-Cyano-3-fluorophenyl esters | F. HOFFMANN-LA ROCHE AG (CH) | 1992-01-08 | — | — | EP | disclosed |
| EP-0457105-A1 | Chiral dioxanes as components of liquid crystal mixtures | F. HOFFMANN-LA ROCHE AG (CH) | 1991-11-21 | — | — | EP | disclosed |
| US-5013477-A | Alkenylbicyclohexane liquid crystals | HOFFMANN-LA ROCHE INC. (US) | 1991-05-07 | — | — | US | disclosed |
| EP-0315014-A2 | Halogenated benzene derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-05-10 | — | — | EP | disclosed |
| EP-0261614-A2 | Liquid crystal display cell | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-03-30 | — | — | EP | disclosed |
| EP-0167912-A2 | Liquid crystal mixtures containing compounds with a 4-alkenyl or 2Z-alkenyl lateral chain | F. HOFFMANN-LA ROCHE AG (CH) | 1986-01-15 | — | — | EP | disclosed |