SCHEMBL9166382

SCHEMBL9166382

CCCCCC1CCC(C=CCCc2ccc(C)cc2)CC1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.36
S1PR3 Q99500 2/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C8 P10632 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
KCNH2 Q12809 3/20 0.34
TNNC1 P63316 3/20 0.33
ITGB3 P05106 1/20 0.33
ITGA2B P08514 1/20 0.33
TP53 P04637 1/20 0.33
HRH3 Q9Y5N1 1/20 0.33
SPHK1 Q9NYA1 4/20 0.33
GPR52 Q9Y2T5 1/20 0.32
GRM2 Q14416 1/20 0.32
NMT1 P30419 1/20 0.31
SGPL1 O95470 1/20 0.31
S1PR4 O95977 1/20 0.31
S1PR1 P21453 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9166377 1.00 MAOB (0.36) MAOBS1PR3CYP3A4CYP2C8CYP2D6
SCHEMBL9166385 1.00 MAOB (0.36) MAOBS1PR3CYP3A4CYP2C8CYP2D6
SCHEMBL9248283 0.92 MAOA (0.37) MAOBS1PR3CYP3A4CYP2C8CYP2D6
SCHEMBL9248286 0.92 MAOA (0.37) MAOBS1PR3CYP3A4CYP2C8CYP2D6
SCHEMBL9157596 0.88 ESR1 (0.45) MAOBS1PR3CYP3A4CYP2C8CYP2D6
SCHEMBL9157578 0.88 ESR1 (0.45) MAOBS1PR3CYP3A4CYP2C8CYP2D6
SCHEMBL9465921 0.88 S1PR3 (0.35) S1PR3CYP3A4CYP2C8CYP2D6CYP2C9
SCHEMBL9159036 0.88 MAOB (0.35) MAOBS1PR3CYP3A4CYP2C8CYP2D6
SCHEMBL9159039 0.88 MAOB (0.35) MAOBS1PR3CYP3A4CYP2C8CYP2D6
SCHEMBL9167123 0.88 KCNH2 (0.46) MAOBS1PR3CYP3A4CYP2C8CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0442306-B1 (4E-cyclohexyl-3-butenyl)phenyl derivatives HOFFMANN LA ROCHE (CH) 1995-04-12 EP disclosed
US-5204018-A LIQUID CRYSTALS HOFFMANN-LA ROCHE INC. (US) 1993-04-20 US disclosed
EP-0442306-A2 (4E-cyclohexyl-3-butenyl)phenyl derivatives F. Hoffmann-La Roche AG (CH) 1991-08-21 EP disclosed