Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9161558 | 0.94 | P2RY14 (0.40) | P2RY14LMNATP53SMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL9164291 | 0.91 | P2RY14 (0.39) | P2RY14LMNATP53S1PR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9164525 | 0.91 | S1PR1 (0.40) | S1PR1THRATHRBPTPN11MAPT | |
| Hydrochloric Acid SCHEMBL9163469 | 0.89 | P2RY14 (0.41) | P2RY14LMNATP53S1PR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9164860 | 0.89 | SMN1; SMN2 (0.50) | P2RY14LMNATP53SMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL9168443 | 0.88 | PTPN11 (0.42) | P2RY14LMNATP53SMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL9165654 | 0.88 | PTPN11 (0.42) | P2RY14LMNATP53SMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL9167609 | 0.87 | P2RY14 (0.41) | P2RY14LMNATP53SMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL9164136 | 0.86 | P2RY14 (0.54) | P2RY14LMNASMN1; SMN2HTTMAPT | |
| Hydrochloric Acid SCHEMBL9161430 | 0.86 | P2RY14 (0.54) | P2RY14LMNASMN1; SMN2HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432189-A | Bis-aryl amide and urea antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1995-07-11 | — | — | US | disclosed |
| US-5350759-A | Bis-aryl urea compounds | WISSNER ALLAN (US) | 1994-09-27 | — | — | US | disclosed |
| US-5231182-A | Platelet activating factor inhibitor | AMERICAN CYANAMID COMPANY (US) | 1993-07-27 | — | — | US | disclosed |
| US-5225425-A | Respiratory system disorders | AMERICAN CYANAMID COMPANY (US) | 1993-07-06 | — | — | US | disclosed |
| US-5128351-A | BIS-ARYL AMIDE AND UREA ANTAGONISTS OF PLATELET ACTIVATING FACTOR | AMERICAN CYANAMID COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
| US-5077409-A | Reducing hydroxy bis-aryl amide, acylating, hydrolyzing, sulfonating, halogenating, alkylating with nitrogen heterocycle | AMERICAN CYANAMID COMPANY (US) | 1991-12-31 | — | — | US | disclosed |