SCHEMBL916698

SCHEMBL916698

CCC(Oc1cc(C2=NOC3(CCOC3)C2)ccc1OCC(F)(F)F)C(=O)O

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SSTR5 P35346 8/20 0.37
PPARA Q07869 2/20 0.35
PPARD Q03181 2/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.33
F2 P00734 2/20 0.32
F10 P00742 2/20 0.32
PRSS1 P07477 2/20 0.32
PPARG P37231 1/20 0.32
PDE4A P27815 1/20 0.31
PDE4B Q07343 1/20 0.31
PDE4C Q08493 1/20 0.31
PDE4D Q08499 1/20 0.31
TRPV1 Q8NER1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL917099 0.88 PPARA (0.37) SSTR5PPARAF2F10PRSS1
SCHEMBL918309 0.86 S1PR1 (0.33) SSTR5
SCHEMBL3674939 0.84 PTGDR2 (0.35) SSTR5PPARAPPARDPTGDR2
SCHEMBL3956529 0.84 SSTR5 (0.34) SSTR5PPARAF2F10PRSS1
SCHEMBL917152 0.84 SSTR5 (0.40) SSTR5
SCHEMBL917691 0.83 KDM4E (0.37) SSTR5PDE4APDE4BPDE4CPDE4D
SCHEMBL3818690 0.83 SSTR5 (0.33) SSTR5PPARAPDE4APDE4BPDE4C
SCHEMBL917561 0.82 PPARA (0.33) SSTR5PPARAPPARG
SCHEMBL917546 0.81 PDE4D (0.32) SSTR5PDE4D
SCHEMBL916639 0.80 SSTR5 (0.33) SSTR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110021473-A1 INHIBITORS OF PHOSPHODIESTERASE TYPE-IV RANBAXY LABORATORIES LIMITED 2011-01-27 US claimed
US-20110021473-A1 INHIBITORS OF PHOSPHODIESTERASE TYPE-IV RANBAXY LABORATORIES LIMITED 2011-01-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110021473-A1 INHIBITORS OF PHOSPHODIESTERASE TYPE-IV PDE4A, PDE4B, PDE4C SSTR5 3863/4885PPARA 3224/4885PPARD 2478/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.