SCHEMBL9167130

SCHEMBL9167130

N#Cc1ccc(C(CCCCCl)n2ccnc2)cc1

nearest known ligand 0.66

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 11/20 0.66
CYP17A1 P05093 7/20 0.53
CYP11B1 P15538 1/20 0.45
CYP11B2 P19099 1/20 0.45
TBXAS1 P24557 1/20 0.41
CYP26A1 O43174 1/20 0.41
CYP3A4 P08684 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1507993 0.96 CYP19A1 (0.67) CYP19A1CYP17A1CYP11B1CYP11B2TBXAS1
SCHEMBL7859488 0.86 CYP19A1 (0.67) CYP19A1CYP17A1CYP11B1CYP11B2
SCHEMBL8156789 0.83 CYP19A1 (0.66) CYP19A1CYP17A1CYP11B1CYP11B2
SCHEMBL9784379 0.83 CYP19A1 (0.66) CYP19A1CYP17A1
SCHEMBL8149595 0.83 CYP19A1 (0.66) CYP19A1CYP17A1CYP11B1CYP11B2
SCHEMBL8110779 0.80 CYP19A1 (1.00) CYP19A1CYP17A1CYP11B1CYP11B2
SCHEMBL1507781 0.80 CYP19A1 (0.66) CYP19A1CYP17A1CYP11B1CYP11B2
SCHEMBL7855823 0.80 CYP19A1 (0.62) CYP19A1CYP17A1CYP11B1CYP11B2
SCHEMBL1508005 0.79 CYP19A1 (0.69) CYP19A1CYP17A1CYP11B1CYP11B2CYP26A1
SCHEMBL8408606 0.77 CYP19A1 (1.00) CYP19A1CYP17A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5473078-A Aromatase inhibiting compounds CIBA-GEIGY CORPORATION (US) 1995-12-05 US disclosed
US-5352795-A Condensing triazolylmethylbenzonitrile with fluorobenzonitrile under basic conditions using alkali metal alkoxide CIBA-GEIGY CORPORATION (US) 1994-10-04 US disclosed
US-5112845-A Inhibitors of estrogen synthesis, veterinary medicine CIBA-GEIGY CORPORATION (US) 1992-05-12 US disclosed
US-5071861-A Aromatase enzyme inhibitor; antiestrogens CIBA-GEIGY CORPORATION (US) 1991-12-10 US disclosed
US-4978672-A Alpha-heterocyclc substituted tolunitriles CIBA-GEIGY CORPORATION (US) 1990-12-18 US disclosed
US-4937250-A AROMATASE ENZYME INHIBITORS CIBA-GEIGY CORPORATION (US) 1990-06-26 US disclosed