Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5095050 | 0.90 | PLA2G2A (0.71) | PLA2G2ATSHRSMPD1MAPTTP53 | |
| SCHEMBL7089932 | 0.90 | PLA2G2A (0.66) | PLA2G2ATSHRSMPD1MAPTTP53 | |
| SCHEMBL1568668 | 0.90 | PLA2G2A (0.71) | PLA2G2ATSHRSMPD1MAPTTP53 | |
| SCHEMBL25327393 | 0.90 | PLA2G2A (0.71) | PLA2G2ATSHRSMPD1MAPTTP53 | |
| SCHEMBL1822124 | 0.90 | PLA2G2A (0.66) | PLA2G2ATSHRSMPD1MAPTTP53 | |
| SCHEMBL25328188 | 0.90 | PLA2G2A (0.71) | PLA2G2ATSHRSMPD1MAPTTP53 | |
| SCHEMBL971768 | 0.90 | PLA2G2A (0.71) | PLA2G2ATSHRSMPD1MAPTTP53 | |
| SCHEMBL2710788 | 0.90 | PLA2G2A (0.66) | PLA2G2ATSHRSMPD1MAPTTP53 | |
| SCHEMBL317989 | 0.90 | PLA2G2A (0.71) | PLA2G2ATSHRSMPD1MAPTTP53 | |
| SCHEMBL5086867 | 0.90 | PLA2G2A (0.71) | PLA2G2ATSHRSMPD1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |