Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 18/20 | 0.67 |
| ▸ | BCHE | P06276 | 15/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10486940 | 0.89 | ACHE (0.67) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL10352021 | 0.85 | ACHE (0.67) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL9168192 | 0.83 | ACHE (0.64) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL10635198 | 0.81 | ACHE (0.67) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL12043410 | 0.81 | ACHE (1.00) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL30410668 | 0.81 | ACHE (1.00) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL9171159 | 0.81 | ACHE (0.63) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL10631791 | 0.80 | ACHE (0.62) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL9173696 | 0.78 | ACHE (0.61) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL10351751 | 0.78 | ACHE (0.67) | ACHEBCHECHRM1GRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0285018-B1 | Substituted 9-Amino-Spiro [cycloalkyl[b]quinoline-2,1'cycloalkanes], a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-05-31 | — | — | EP | disclosed |
| US-4855479-A | Substituted 9-amino-spiro(cycloalkyl(B)quinoline-2,1'cycloalkanes | SHUTSKE GREGORY M (US) | 1989-08-08 | — | — | US | disclosed |
| US-4806646-A | Substituted 9-amino-spiro[cycloalkyl[B]quinoline-2,1'cycloalkanes] | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| US-4762841-A | Substituted 9-amino-spiro(cycloalkyl(b)quinoline-2,1'cycloalkanes) | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-08-09 | — | — | US | disclosed |