Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.74 |
| ▸ | BLM | P54132 | 1/20 | 0.74 |
| ▸ | CNR1 | P21554 | 11/20 | 0.46 |
| ▸ | CNR2 | P34972 | 11/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9171634 | 0.95 | PLA2G2A (0.85) | PLA2G2ABLMCNR1CNR2THRB | |
| SCHEMBL9168070 | 0.94 | PLA2G2A (0.66) | PLA2G2ABLMCNR1CNR2THRB | |
| SCHEMBL9171261 | 0.92 | PLA2G2A (0.64) | PLA2G2ABLMCNR1CNR2 | |
| SCHEMBL9167296 | 0.92 | PLA2G2A (0.64) | PLA2G2ABLMCNR1CNR2 | |
| SCHEMBL9172120 | 0.91 | PLA2G2A (0.63) | PLA2G2ABLMCNR1CNR2THRB | |
| SCHEMBL9166116 | 0.91 | PLA2G2A (0.63) | PLA2G2ABLMCNR1CNR2MEN1 | |
| SCHEMBL9417552 | 0.91 | PLA2G2A (0.62) | PLA2G2ABLMCNR1CNR2THRB | |
| SCHEMBL9172034 | 0.89 | PLA2G2A (0.60) | PLA2G2ABLMCNR1CNR2THRB | |
| SCHEMBL9170589 | 0.88 | PLA2G2A (0.62) | PLA2G2ABLMCNR1CNR2MEN1 | |
| SCHEMBL9167792 | 0.88 | PLA2G2A (0.73) | PLA2G2ABLMCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |