Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.70 |
| ▸ | FLT1 | P17948 | 5/20 | 0.57 |
| ▸ | FLT4 | P35916 | 5/20 | 0.57 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.52 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | BMP4 | P12644 | 2/20 | 0.50 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.46 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7616736 | 0.83 | KDR (1.00) | KDRFLT1FLT4ACVR1PRKAB1 | |
| SCHEMBL14424408 | 0.81 | KDR (0.85) | KDRFLT1FLT4ACVR1PRKAB1 | |
| SCHEMBL9168815 | 0.77 | KDR (0.59) | KDRFLT1FLT4ACVR1PRKAB1 | |
| SCHEMBL7610636 | 0.77 | KDR (1.00) | KDRFLT1FLT4ACVR1PRKAB1 | |
| SCHEMBL9688658 | 0.77 | NPC1 (0.48) | KDR | |
| SCHEMBL7618559 | 0.76 | KDR (0.77) | KDRFLT1FLT4ACVR1PRKAB1 | |
| SCHEMBL5405900 | 0.76 | KDR (0.72) | KDRFLT1FLT4ACVR1PRKAB1 | |
| SCHEMBL7618521 | 0.76 | KDR (0.77) | KDRFLT1FLT4ACVR1PRKAB1 | |
| SCHEMBL9175179 | 0.75 | BMP4 (0.50) | KDRFLT1FLT4GAKBMP4 | |
| SCHEMBL14437843 | 0.74 | KDR (0.68) | KDRFLT1FLT4ACVR1PRKAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420128-A | Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-05-30 | — | — | US | disclosed |