Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9168952 | 1.00 | HRH3 (0.45) | HRH3KCNH2GRIA1GRIA2GRIA3 | |
| SCHEMBL9168970 | 1.00 | HRH3 (0.45) | HRH3KCNH2GRIA1GRIA2GRIA3 | |
| SCHEMBL9168960 | 1.00 | HRH3 (0.45) | HRH3KCNH2GRIA1GRIA2GRIA3 | |
| SCHEMBL6459335 | 0.95 | GRIA1 (0.42) | HRH3KCNH2GRIA1GRIA2GRIA3 | |
| SCHEMBL6459328 | 0.95 | GRIA1 (0.42) | HRH3KCNH2GRIA1GRIA2GRIA3 | |
| SCHEMBL6459324 | 0.95 | GRIA1 (0.42) | HRH3KCNH2GRIA1GRIA2GRIA3 | |
| SCHEMBL6459320 | 0.95 | GRIA1 (0.42) | HRH3KCNH2GRIA1GRIA2GRIA3 | |
| SCHEMBL91812 | 0.95 | GRIA1 (0.42) | HRH3KCNH2GRIA1GRIA2GRIA3 | |
| SCHEMBL8044943 | 0.91 | GRIA1 (0.40) | HRH3KCNH2GRIA1GRIA2GRIA3 | |
| SCHEMBL8044940 | 0.91 | GRIA1 (0.40) | HRH3KCNH2GRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0464648-B1 | 4-Cyano-3-fluorophenyl esters | HOFFMANN LA ROCHE (CH) | 1995-12-06 | — | — | EP | disclosed |
| US-5413734-A | 4-cyano-3-fluorophenyl esters | HOFFMANN-LA ROCHE INC. (US) | 1995-05-09 | — | — | US | disclosed |
| EP-0450025-B1 | TEMPERATURE COMPENSATION OF LIQUID-CRYSTAL PARAMETERS | HOFFMANN LA ROCHE (CH) | 1995-01-18 | — | — | EP | disclosed |
| US-5309265-A | Short pitch LC layer with a temperature independent λ0 and containing a nematic LC doped with plural chiral additives having the same twist sense | HOFFMANN-LA ROCHE INC. (US) | 1994-05-03 | — | — | US | disclosed |
| US-5185098-A | Liquid crystalline mixtures containing 3,4-difluorophenyl-substituted bicyclohexyls | HOFFMANN-LA ROCHE INC. (US) | 1993-02-09 | — | — | US | disclosed |
| EP-0464648-A1 | 4-Cyano-3-fluorophenyl esters | F. HOFFMANN-LA ROCHE AG (CH) | 1992-01-08 | — | — | EP | disclosed |
| EP-0450025-A1 | TEMPERATURE COMPENSATION OF LIQUID-CRYSTAL PARAMETERS. | HOFFMANN LA ROCHE (CH) | 1991-10-09 | — | — | EP | disclosed |
| WO-1991006613-A1 | TEMPERATURE COMPENSATION OF LIQUID-CRYSTAL PARAMETERS | F.HOFFMANN-LA ROCHE AG (CH) | 1991-05-16 | — | — | WO | disclosed |