Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.53 |
| ▸ | LMNA | P02545 | 7/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | STAT3 | P40763 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9170163 | 0.97 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAHTTKMT2ASTAT3 | |
| Bromide SCHEMBL9165825 | 0.92 | EPHX2 (0.50) | SMN1; SMN2LMNAHTTKMT2AEPHX2 | |
| Bromide SCHEMBL9159837 | 0.90 | KMT2A (0.42) | SMN1; SMN2LMNAHTTKMT2AEPHX2 | |
| Bromide SCHEMBL9165222 | 0.90 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAHTTKMT2ASTAT3 | |
| Bromide SCHEMBL9164823 | 0.90 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAHTTKMT2ASTAT3 | |
| Bromide SCHEMBL9169872 | 0.89 | LMNA (0.41) | SMN1; SMN2LMNAHTTKMT2A | |
| Bromide SCHEMBL9166469 | 0.89 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAHTTKMT2ASTAT3 | |
| Bromide SCHEMBL9168069 | 0.88 | EPHX2 (0.50) | SMN1; SMN2LMNAHTTKMT2AEPHX2 | |
| Bromide SCHEMBL9164522 | 0.88 | PLA2G4B (0.44) | MAPT | |
| Bromide SCHEMBL9168409 | 0.88 | MAPT (0.46) | SMN1; SMN2LMNAHTTMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432189-A | Bis-aryl amide and urea antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1995-07-11 | — | — | US | disclosed |
| US-5350759-A | Bis-aryl urea compounds | WISSNER ALLAN (US) | 1994-09-27 | — | — | US | disclosed |
| US-5231182-A | Platelet activating factor inhibitor | AMERICAN CYANAMID COMPANY (US) | 1993-07-27 | — | — | US | disclosed |
| US-5225425-A | Respiratory system disorders | AMERICAN CYANAMID COMPANY (US) | 1993-07-06 | — | — | US | disclosed |
| US-5128351-A | BIS-ARYL AMIDE AND UREA ANTAGONISTS OF PLATELET ACTIVATING FACTOR | AMERICAN CYANAMID COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
| US-5077409-A | Reducing hydroxy bis-aryl amide, acylating, hydrolyzing, sulfonating, halogenating, alkylating with nitrogen heterocycle | AMERICAN CYANAMID COMPANY (US) | 1991-12-31 | — | — | US | disclosed |