Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GRK6 | P43250 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Silver SCHEMBL9169627 | 0.90 | MEN1 (0.46) | KMT2AMEN1ALDH1A1HTTKDM4E | |
| SCHEMBL10625698 | 0.89 | MEN1 (0.47) | KMT2AMEN1ALDH1A1HTTKDM4E | |
| SCHEMBL9169637 | 0.88 | MEN1 (0.46) | KMT2AMEN1ALDH1A1HTTKDM4E | |
| Silver SCHEMBL9636538 | 0.78 | CYP1A2 (0.35) | ALDH1A1NPC1RAB9AMAPTPDGFRB | |
| Silver SCHEMBL9169208 | 0.76 | CYP3A4 (0.34) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL2494275 | 0.74 | MAPT (0.47) | ALDH1A1MAPTGAASMN1; SMN2POLB | |
| Silver SCHEMBL9173642 | 0.74 | MAPT (0.40) | KMT2AMEN1ALDH1A1MAPTGAA | |
| Silver SCHEMBL9171696 | 0.73 | TDP1 (0.40) | ALDH1A1KDM4EMAPTPDGFRBPDGFRA | |
| Silver SCHEMBL9169203 | 0.73 | DTYMK (0.41) | MAPTPOLB | |
| Silver SCHEMBL9636534 | 0.73 | CYP1A2 (0.47) | MAPTPDGFRBPDGFRAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0144087-B2 | Heat-developable color light-sensitive material | KONISHIROKU PHOTO IND (JP) | 1995-05-24 | — | — | EP | disclosed |
| EP-0174135-B2 | HEAT-DEVELOPABLE COLOR LIGHT-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1992-06-17 | — | — | EP | disclosed |
| EP-0144087-B1 | HEAT-DEVELOPABLE COLOR LIGHT-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1990-04-18 | — | — | EP | disclosed |
| EP-0136142-B1 | THERMALLY DEVELOPABLE, LIGHT-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1990-04-11 | — | — | EP | disclosed |
| US-4840882-A | CONTAINING A VINYL SULFONYL HARDENER | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1989-06-20 | — | — | US | disclosed |
| EP-0174135-B1 | HEAT-DEVELOPABLE COLOR LIGHT-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1989-04-26 | — | — | EP | disclosed |
| US-4770981-A | MULTILAYER, DIFFUSION TRANSFER MATERIAL HAVING SPECIFIC BINDER CONCENTRATION; ANTIFOGGING AGENTS; COLOR SEPARATION; PHOTOTHERMOGRAPHY; DRY TREATMENT | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1988-09-13 | — | — | US | disclosed |
| US-4584267-A | SILVER HALIDE, SILVER SALT, REDUCING AGENT, AND BINDER OF GELATIN OR DERIVATIVE AND POLYVINYL ALCOHOL | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1986-04-22 | — | — | US | disclosed |
| EP-0174135-A2 | Heat-developable color light-sensitive material | KONICA CORPORATION (JP) | 1986-03-12 | — | — | EP | disclosed |
| US-4543309-A | BENZOTRIAZOLE SILVER SALT, REDUCING AGENT, BINDER, AMINO-MERCAPTO TRIAZOLE | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1985-09-24 | — | — | US | disclosed |
| EP-0144087-A2 | Heat-developable color light-sensitive material | KONICA CORPORATION (JP) | 1985-06-12 | — | — | EP | disclosed |
| EP-0136142-A2 | Thermally developable, light-sensitive material | KONICA CORPORATION (JP) | 1985-04-03 | — | — | EP | disclosed |