Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10625723 | 0.98 | MAPT (0.41) | MAPTTDP1TSHRMEN1POLB | |
| SCHEMBL9173652 | 0.97 | MAPT (0.40) | MAPTTDP1TSHRMEN1POLB | |
| SCHEMBL13318840 | 0.92 | MAPT (0.41) | MAPTTDP1TSHRMEN1POLB | |
| SCHEMBL2494275 | 0.84 | MAPT (0.47) | MAPTTDP1TSHRPOLBCYP3A4 | |
| Silver SCHEMBL9168043 | 0.79 | GAA (0.41) | MAPTTSHRMEN1POLBKMT2A | |
| SCHEMBL1019898 | 0.79 | GAA (0.44) | MAPTTSHRMEN1KMT2ACYP3A4 | |
| SCHEMBL10623115 | 0.79 | PGK1 (0.43) | MAPTTSHRMEN1KMT2ACYP3A4 | |
| Silver SCHEMBL9168921 | 0.77 | PGK1 (0.42) | TSHRCYP3A4ALDH1A1LMNA | |
| Silver SCHEMBL9169203 | 0.77 | DTYMK (0.41) | MAPTTDP1TSHRPOLBCYP3A4 | |
| Silver SCHEMBL9169208 | 0.77 | CYP3A4 (0.34) | MAPTTSHRMEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0144087-B2 | Heat-developable color light-sensitive material | KONISHIROKU PHOTO IND (JP) | 1995-05-24 | — | — | EP | disclosed |
| EP-0174135-B2 | HEAT-DEVELOPABLE COLOR LIGHT-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1992-06-17 | — | — | EP | disclosed |
| EP-0144087-B1 | HEAT-DEVELOPABLE COLOR LIGHT-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1990-04-18 | — | — | EP | disclosed |
| EP-0174135-B1 | HEAT-DEVELOPABLE COLOR LIGHT-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1989-04-26 | — | — | EP | disclosed |
| US-4770981-A | MULTILAYER, DIFFUSION TRANSFER MATERIAL HAVING SPECIFIC BINDER CONCENTRATION; ANTIFOGGING AGENTS; COLOR SEPARATION; PHOTOTHERMOGRAPHY; DRY TREATMENT | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1988-09-13 | — | — | US | disclosed |
| EP-0174135-A2 | Heat-developable color light-sensitive material | KONICA CORPORATION (JP) | 1986-03-12 | — | — | EP | disclosed |
| EP-0144087-A2 | Heat-developable color light-sensitive material | KONICA CORPORATION (JP) | 1985-06-12 | — | — | EP | disclosed |