Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.82 |
| ▸ | PLA2G4B | P0C869 | 8/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | RARB | P10826 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326057 | 0.92 | PLA2G2A (0.74) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL1568649 | 0.91 | PLA2G2A (1.00) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL11050536 | 0.91 | PLA2G2A (1.00) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL9171240 | 0.91 | PLA2G2A (1.00) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL31661147 | 0.91 | PLA2G2A (1.00) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL25327655 | 0.91 | PLA2G2A (1.00) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL3905253 | 0.91 | PLA2G2A (1.00) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL13836893 | 0.91 | PLA2G2A (1.00) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL15731864 | 0.91 | PLA2G2A (1.00) | PLA2G2APLA2G4BTP53TSHRRARB | |
| SCHEMBL26455385 | 0.91 | PLA2G2A (1.00) | PLA2G2APLA2G4BTP53TSHRRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601385-A1 | Disubstituted benzoic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | claimed |
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5374772-A | Skin disorders, antiinflammatory agents, cardiovascular disorders | HOFFMANN-LAROCHE INC. (US) | 1994-12-20 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0601385-A1 | Disubstituted benzoic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |
| US-5298652-A | N-substituted glycines, inhibitors of phospholipase A2 | HOFFMANN-LA ROCHE INC. (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |