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Tyrosine

Tyrosine

SCHEMBL9170935

CSCC[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCC(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CC(=O)O)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ SLC7A5 Q01650 1/20 0.43
▸ THRB P10828 1/20 0.39
▸ ITGB3 P05106 1/20 0.39
▸ ITGA2B P08514 1/20 0.39
▸ LNPEP Q9UIQ6 2/20 0.38
▸ ERAP2 Q6P179 1/20 0.38
▸ GSR P00390 1/20 0.36
▸ OPRM1 P35372 1/20 0.35
▸ ALOX15 P16050 1/20 0.34
▸ BLM P54132 1/20 0.34
▸ PMP22 Q01453 1/20 0.34
▸ KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrosine SCHEMBL10424744 0.90 SLC7A5 (0.44) SLC7A5THRBITGB3ITGA2BLNPEP
Tyrosine SCHEMBL8630269 0.86 SLC7A5 (0.58) SLC7A5THRBITGB3ITGA2BLNPEP
Tyrosine SCHEMBL10424737 0.85 SLC7A5 (0.39) SLC7A5THRBITGB3ITGA2BLNPEP
Tyrosine SCHEMBL293997 0.85 NPY4R (0.41) SLC7A5
Tyrosine SCHEMBL27625516 0.84 SLC7A5 (0.60) SLC7A5ALOX15BLMPMP22KMT2A
Lysine SCHEMBL9173541 0.84 ITGB3 (0.41) SLC7A5THRBITGB3ITGA2BLNPEP
Tyrosine SCHEMBL28438814 0.83 SLC7A5 (0.61) SLC7A5THRBITGB3ITGA2BLNPEP
Tyrosine SCHEMBL3507740 0.83 SLC7A5 (0.61) SLC7A5THRBITGB3ITGA2BLNPEP
Tyrosine SCHEMBL27531942 0.83 SLC7A5 (0.61) SLC7A5ALOX15
Tyrosine SCHEMBL28464298 0.82 SLC7A5 (0.47) SLC7A5THRBITGB3ITGA2BLNPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0417524-B1 Antigens and polypeptides derived from babesia (12D3 antigen) COMMW SCIENT IND RES ORG (AU) 1995-05-03 — — EP claimed
EP-0417524-A1 Antigens and polypeptides derived from babesia (12D3 antigen) COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 1991-03-20 — — EP claimed
EP-0417524-B1 Antigens and polypeptides derived from babesia (12D3 antigen) COMMW SCIENT IND RES ORG (AU) 1995-05-03 — — EP disclosed
EP-0417524-A1 Antigens and polypeptides derived from babesia (12D3 antigen) COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 1991-03-20 — — EP disclosed
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